INDOMETHACIN ENHANCES SERUM 2'5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS WITH HEPATITIS-B AND HEPATITIS-C VIRUS CHRONIC ACTIVE HEPATITIS
INDOMETHACIN ENHANCES SERUM 2'5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS WITH HEPATITIS-B AND HEPATITIS-C VIRUS CHRONIC ACTIVE HEPATITIS
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DOI：
10.1016/s0168-8278(05)80606-3
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发表时间：
1994-12-01
影响因子：
25.7
通讯作者：
GASBARRINI, G
中科院分区：
文献类型：
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作者：
ANDREONE, P;CURSARO, C;GASBARRINI, G
激活花生四烯酸代谢似乎是干扰素诱导抗病毒蛋白合成的受体后机制之一。本研究评估了21例乙型或丙型慢性活动性肝炎患者急性给予干扰素- α、吲哚美辛和干扰素-a +吲哚美辛诱导的血清2′5′-低聚腺苷酸合成酶水平的变化。在基础条件下和给药干扰素- α、吲哚美辛及干扰素- α +吲哚美辛后8 h采集血清进行2′5′-低聚腺苷酸合成酶测定。与对照组（平均+/- SE） （40.2 +/- 7.9 pg/dl）相比，干扰素- α后血清2'5'-低聚腺苷酸合成酶浓度显著增加1.5倍(63.4 +/- 11,p
Activation of the arachidonic acid metabolism seems to be one of the post-receptor mechanisms by which interferon-alpha induces antiviral protein synthesis. In this study, we evaluated the changes on serum 2'5'-oligoadenylate synthetase levels induced by acute administration of interferon-alpha, indomethacin and interferon-a plus indomethacin in 21 patients with hepatitis B or C virus chronic active hepatitis. Serum samples for 2'5'-oligoadenylate synthetase determination were collected in basal conditions and 8 h after the administration of interferon-alpha, indomethacin and interferon-alpha plus indomethacin. Compared to control value (mean +/- SE) (40.2 +/- 7.9 pg/dl) serum 2'5'-oligoadenylate synthetase concentration was significantly increased 1.5-fold after interferon-alpha (63.4 +/- 11, p