Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers
Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers
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DOI：
10.1007/s00234-007-0317-y
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发表时间：
2008-02-01
期刊：
影响因子：
2.8
通讯作者：
Ogawa, Akira
中科院分区：
文献类型：
--
作者：
Fujiwara, Shunrou;Sasaki, Makoto;Ogawa, Akira
引言我们试图评估1.6 mm各向同性体素扩散张量成像（DTI）纤维束成像在3 T可视化边缘系统神经束的可行性。方法我们检查了20名健康志愿者，采用常规DTI，体素尺寸为1.6 x 1.6 x 3.0 mm，分辨率DTI，体素尺寸为1.6 x 1.6 x 1.6 mm，并生成三个边缘神经束的追踪图：穹窿、扣带和钩束。我们直观地评估这些束是否达到了他们的目标，并比较了两种techniques.Results之间的扩散参数的穹窿，扣带回，钩束的整个途径更容易可视化高分辨率DTI比传统的DTI。其中穹窿伞和钩束颞极附近的显示率分别为83%和100%，高于常规DTI显示率（分别为63%和83%，P < 0.05和P < 0.01）。高分辨率DTI在穹窿、扣带回和钩束的各向异性分数值显著高于常规DTI（P < 0.01）;与此相反，除穹窿纤维外，其余纤维的表观弥散系数值在两种技术间无明显变化。3 T各向同性体素DTI是一种可行的可视化工具，可以提高边缘系统神经束追踪的精度。
Introduction We attempted to assess the feasibility of a 1.6-mm isotropic voxel diffusion tensor imaging (DTI) tractography at 3T in visualizing nerve bundles in the limbic system.Methods We examined 20 healthy volunteers by conventional DTI with a voxel size of 1.6 x 1.6 x 3.0 mm and by high-resolution DTI with a voxel size of 1.6 x 1.6 x 1.6 mm and generated tractographs of three limbic nerve bundles: the fornix, cingulum, and uncinate fasciculus. We visually assessed whether these bundles reached their targets and compared their diffusion parameters between the two techniques.Results The entire pathways of the fornix, cingulum, and uncinate fasciculus were more readily visualized by high-resolution DTI than by conventional DTI. Among these, the fimbria of the fornix and the uncinate fasciculus adjacent to the temporal pole were identified more frequently by high-resolution DTI (visualization rate 83 and 100%, respectively) than by conventional DTI (visualization rate 63 and 83%, respectively) at a statistical significance of P < 0.05 and P < 0.01, respectively). Fractional anisotropy values in the fornix, cingulum, and uncinate fasciculus by high-resolution DTI were significantly higher than those by conventional DTI (P < 0.01); in contrast, the apparent diffusion coefficient values of all these fibers except that of the fornix remained unchanged between the two techniques.Conclusion The 1.6-mm istropic voxel DTI at 3T is a feasible visualization tool and can improve the precision of tracking nerve bundles of the limbic system.