Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue.
Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue.
复制标题
新霉素抑制子宫肌组织中激素刺激的平滑肌收缩。
DOI：
10.1006/bbrc.1994.2656
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发表时间：
1994
影响因子：
3.1
通讯作者：
Phillippe,M
中科院分区：
文献类型：
--
作者：
Phillippe,M
这些研究试图确定新霉素（一种磷脂酶 C 抑制剂）对激素刺激的子宫肌层收缩的影响。在这些研究中，分析了计算机数字化的体外等长收缩数据，以了解在有或没有新霉素的情况下对催产素和氟化铝的反应的收缩活动的变化。新霉素 (1-5 mM) 对催产素和氟化铝刺激的子宫肌层收缩产生剂量相关的抑制作用。新霉素的这种作用在添加后 2-3 分钟内就很明显，并且是完全可逆的，其抑制作用在冲洗后 6-8 分钟内消失。这项研究首次证明了新霉素抑制子宫平滑肌组织中磷脂酰肌醇信号通路的功能作用。
These studies sought to determine the effects of neomycin, a phospholipase C inhibitor, on hormone-stimulated myometrial contractions. For these studies, computer digitalizedin vitroisometric contraction data were analyzed for changes in contractile activity in response to oxytocin and aluminum fluoride with and without neomycin. Neomycin (1-5 mM) produced dose-related inhibition of oxytocin and aluminum fluoride-stimulated myometrial contractions. This neomycin effect was apparent within 2-3 minutes of addition and was completely reversible, with resolution of its inhibitory effects within 6-8 minutes of washout. This study is the first to demonstrate the functional effect of neomycin inhibition of the phosphatidylinositol signaling pathway in myometrial smooth muscle tissue.