Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands.
Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands.
复制标题
唾液腺基底细胞腺瘤和小管腺瘤的免疫组织化学方面。
DOI：
10.1016/s1368-8375(00)00086-5
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发表时间：
2001
期刊：
影响因子：
4.8
通讯作者：
V. C. D. Araújo
中科院分区：
文献类型：
--
作者：
S. D. Sousa;N. S. D. Araújo;Luciana Corrêa;A. M. P. Soubhia;V. C. D. Araújo
基底细胞腺瘤是一种良性的上皮性肿瘤，其组织学外观以基底细胞样细胞为主。这些细胞可以以各种排列方式分布，如实心、小梁、管状和膜状。小管腺瘤也是一种良性肿瘤，由柱状细胞组成，排列成单细胞或双细胞粗行的分支和相互连接的索。对于小管腺瘤是否应该包括在基底细胞腺瘤组织学谱中，研究者之间存在一些分歧。在本研究中，我们比较了细胞角蛋白（CK），波形蛋白和肌肉特异性肌动蛋白的表达，利用免疫组化技术，在3例诊断为基底细胞腺瘤主要是实体型，和3例小管腺瘤。获得的结果显示了两种肿瘤的不同免疫特征。基底细胞腺瘤的实体区域未对任何测试抗体染色;仅当存在肾小管分化时，这些结构在管腔细胞中表达CK 7、8、14和19，在非管腔细胞中表达波形蛋白。另一方面，泪小管腺瘤强烈表达CKs 7和13。所用的抗体组支持两种实体的分离。
Basal cell adenoma is a benign epithelial neoplasm with a uniform histologic appearance dominated by basaloid cells. Those cells may be distributed in various arrangements as solid, trabecular, tubular and membranous. Canalicular adenoma is also a benign neoplasm composed by columnar cells arranged in branching and interconnecting cords of single or double cell thick rows. There is some disagreement among investigators about whether canalicular adenoma should be included within the basal cell adenoma histologic spectrum. In the present study we compared the expression of cytokeratins (CK), vimentin and muscle-specific actin, utilizing immunohistochemical technique, in three cases diagnosed as basal cell adenomas predominantly of the solid type, and three cases of canalicular adenomas. The results obtained showed a distinct immunoprofile for both neoplasms. Solid areas of basal cell adenomas did not stain for any of the tested antibodies; only when there was tubular differentiation, those structures expressed CKs 7, 8, 14, and 19 in luminal cells and vimentin in non-luminal cells. On the other hand, canalicular adenomas strongly expressed CKs 7 and 13. The panel of antibodies utilized supports the separation of the two entities.