Cardiovascular cast model fabrication and casting effectiveness evaluation in fetus with severe congenital heart disease or normal heart
Cardiovascular cast model fabrication and casting effectiveness evaluation in fetus with severe congenital heart disease or normal heart
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严重先天性心脏病或正常心脏胎儿心血管铸型模型制作及铸型效果评估
DOI：
10.1007/s11596-016-1577-8
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发表时间：
2016-04-01
影响因子：
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通讯作者：
Deng, Cheng
中科院分区：
文献类型：
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作者：
Wang, Yu;Cao, Hai-yan;Deng, Cheng
为探讨血管腐蚀技术在制备胎儿心血管铸型模型中的应用及有效性，选取2013年3月至2015年6月在我院行人工流产手术的10例正常胎儿心脏标本（对照组）和18例重度先天性心脏病胎儿标本（病例组）。将铸型材料注入血管腔内制作铸型模型，以显示胎儿心血管系统的真实的几何形态。根据局部解剖结构和不同解剖水平（包括整体水平、房室和大血管系统、左侧和右侧心脏）以及不同妊娠期分析铸件有效性。在我们的研究中，所有标本都成功铸造。局部解剖结构的铸型效果分析显示，平均得分为1.90±1.45 ~ 3.60±0.52，除左心室外，其余局部解剖结构在病例组和对照组之间无显著性差异（P=0.027）。两组间不同解剖水平的铸件有效性比较无显著差异。组内比较也显示房室和大血管系统之间或相应组的左、右心之间的铸型效果未分化。孕晚期组大血管系统灌注评分显著高于孕中期组（P=0.046），而其他解剖水平无差异。血管腐蚀技术可成功应用于胎儿心血管铸型模型的制作。对胎儿严重先天性心脏病和正常心脏的三维解剖显示也是一种可靠的方法。
To investigate the application and effectiveness of vascular corrosion technique in preparing fetal cardiovascular cast models, 10 normal fetal heart specimens with other congenital disease (control group) and 18 specimens with severe congenital heart disease (case group) from induced abortions were enrolled in this study from March 2013 to June 2015 in our hospital. Cast models were prepared by injecting casting material into vascular lumen to demonstrate real geometries of fetal cardiovascular system. Casting effectiveness was analyzed in terms of local anatomic structures and different anatomical levels (including overall level, atrioventricular and great vascular system, left-sided and right-sided heart), as well as different trimesters of pregnancy. In our study, all specimens were successfully casted. Casting effectiveness analysis of local anatomic structures showed a mean score from 1.90±1.45 to 3.60±0.52, without significant differences between case and control groups in most local anatomic structures except left ventricle, which had a higher score in control group (P=0.027). Inter-group comparison of casting effectiveness in different anatomical levels showed no significant differences between the two groups. Intra-group comparison also revealed undifferentiated casting effectiveness between atrioventricular and great vascular system, or left-sided and right-sided heart in corresponding group. Third-trimester group had a significantly higher perfusion score in great vascular system than second-trimester group (P=0.046), while the other anatomical levels displayed no such difference. Vascular corrosion technique can be successfully used in fabrication of fetal cardiovascular cast model. It is also a reliable method to demonstrate three-dimensional anatomy of severe congenital heart disease and normal heart in fetus.