RESPONSE BIAS IN A CASE-CONTROL STUDY - ANALYSIS UTILIZING COMPARATIVE DATA CONCERNING LEGAL ABORTIONS FROM 2 INDEPENDENT SWEDISH STUDIES
RESPONSE BIAS IN A CASE-CONTROL STUDY - ANALYSIS UTILIZING COMPARATIVE DATA CONCERNING LEGAL ABORTIONS FROM 2 INDEPENDENT SWEDISH STUDIES
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DOI：
10.1093/oxfordjournals.aje.a116173
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发表时间：
1991-11-01
影响因子：
5
通讯作者：
MEIRIK, O
中科院分区：
文献类型：
--
作者：
LINDEFORSHARRIS, BM;EKLUND, G;MEIRIK, O
瑞典对年轻女性乳腺癌的两项流行病学研究中关于合法堕胎的独立报告进行了比较，这两项研究覆盖了相同的女性，并重叠了相同的时间段，以估计推定的反应偏差。其中一项研究使用病例对照方法，通过对317例病例和512名对照的回顾性访谈获得数据。另一项研究基于全国范围内合法堕胎登记的客观记录信息。分析表明，这两项研究的优势比为1.5%(95%可信区间为1.1-2.1%)，观察值为22.4%(p<；0.007)，与病例中高报病例相比，对照组中少报以前的人工流产的比率为22.4%。这种反应偏差可能解释了乳腺癌风险增加的趋势，根据几项病例对照研究，乳腺癌似乎与人工流产有关。
Independent reports of legal abortions in two Swedish epidemiologic studies of breast cancer in young women, covering the same women and overlapping the same time period, have been compared in order to estimate a putative response bias. One study used case-control methods and obtained data by retrospective interviews from 317 cases and 512 controls. The other study was based on objectively documented information from a nationwide registry covering legally induced abortions. Analysis demonstrated a ratio between the odds ratios from the two studies of 1.5 (95 percent confidence interval 1.1-2.1) and an observed ratio of 22.4 (p < 0.007) between underreporting of previous induced abortions among controls relative to overreporting among cases. This response bias may explain the tendency toward increased risk of breast cancer which, according to several case-control studies, appears to be associated with induced abortion.