Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition
Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition
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DOI：
10.1021/ol027382t
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发表时间：
2003-02-06
期刊：
影响因子：
5.2
通讯作者：
Yeleswarapu, KR
中科院分区：
文献类型：
--
作者：
Pal, M;Parasuraman, K;Yeleswarapu, KR
研究了水相中无铜钯催化的O/N-炔丙基键断裂反应，为酚类和苯胺类化合物的脱保护提供了一种温和、简便的方法。该方法可用于从芳基醚和胺中选择性去除炔丙基，而不影响底物中存在的各种未保护的官能团。讨论了反应机理和反应范围。
A copper-free palladium-mediated cleavage of O/N-propargyl bonds in aqueous media has been investigated, affording a mild and convenient method for the deprotection of phenols and anilines. The methodology could be utilized for the selective removal of propargyl groups from aryl ethers and amines without affecting a variety of unprotected functional groups present in the substrates. The mechanism and scope of the reaction is discussed.