Treatment of benign and atypical nevi with the normal-mode ruby laser and the Q-switched ruby laser: clinical improvement but failure to completely eliminate nevomelanocytes.
Treatment of benign and atypical nevi with the normal-mode ruby laser and the Q-switched ruby laser: clinical improvement but failure to completely eliminate nevomelanocytes.
复制标题
使用正常模式红宝石激光和 Q 开关红宝石激光治疗良性和非典型痣：临床改善，但未能完全消除痣黑素细胞。
作者：
Daniella Duke;H. Randolph Byers;A. Sober;R. Anderson;J. Grevelink
客观化
目的：探讨正常模式和调Q红宝石激光(694 Nm)对良性、不典型和先天性色素痣的影响。
设计
用Q开关红宝石激光或普通红宝石激光或同时用Q开关红宝石激光或普通红宝石激光治疗31例色素痣，另一半用铝箔覆盖，未治疗。
设置
一个附属于大学的、以医院为基础的激光中心。
病人
16例患者共31例黑色素细胞痣纳入研究。
干预措施
至少两名皮肤科医生对所有色素痣进行评估，以评估临床非典型性的程度。在治疗前、治疗后立即和每次随访时拍摄照片。数字成像系统被用来评估测量长度的基底膜带中的黑素细胞数量。
主要结果衡量标准
对照组和治疗组各取三个单独的读数(每单位长度的黑素细胞数)，然后进行比较以量化治疗效果。所有的分析都使用了3次测量的平均值。用配对t检验比较治疗侧和非治疗侧。
结果
在4周的随访中，16例(52%)的色素痣患者治疗侧色素减少。
结论
无一例病变组织学上完全去除了所有新生黑色素细胞。因此，无论在临床还是组织学上，一两次激光治疗都不足以导致病变完全切除。
OBJECTIVE
To evaluate the effect of normal-mode and Q-switched ruby laser light (694 nm) on nevomelanocytes of benign, atypical, and congenital nevi.
DESIGN
Half of the lesion of each of 31 nevi was treated with either the Q-switched ruby laser or the normal-mode ruby laser or both; the other half of the lesion was covered with aluminum foil and was not treated.
SETTING
A university-affiliated, hospital-based laser center.
PATIENTS
Sixteen patients with a total of 31 melanocytic nevi were enrolled in the study.
INTERVENTIONS
All nevi were evaluated by at least 2 dermatologists to assess the degree of clinical atypia. Photographs were taken before and immediately after treatment and at each follow-up visit. The digital imaging system was used to evaluate the number of melanocytes in a measured length of basement membrane zone.
MAIN OUTCOME MEASURE
Three individual readings (number of melanocytes per unit length) were taken on both the control and treated halves and then compared to quantitate treatment effect. All analyses used averages from 3 measurements. A Student paired t test was used to compare the treated and untreated sides.
RESULTS
Sixteen (52%) of the nevi showed a clinically visible decrease in pigment on the treatment side at the 4-week follow-up visit.
CONCLUSION
No lesions had complete histologic removal of all nevomelanocytes. Therefore, 1 or 2 laser treatments are not sufficient to cause complete removal of a lesion either clinically or histologically.
调Q红宝石激光治疗太田痣。
影响因子：
13.8
作者：
Taylor,CR;Flotte,TJ;Gange,RW;Anderson,RR
通讯作者：
Anderson,RR
患有发育异常痣的黑色素瘤易发家庭患恶性黑色素瘤的风险较高。
影响因子：
39.2
作者：
Greene,MH;ClarkJr,WH;Tucker,MA;Kraemer,KH;Elder,DE;Fraser,MC
通讯作者：
Fraser,MC
热休克和 UVB 光对表皮角质形成细胞中应激蛋白表达的不同影响。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Maytin,EV
通讯作者：
Maytin,EV