High-throughput sensing of freely flowing particles with optomechanofluidics
High-throughput sensing of freely flowing particles with optomechanofluidics
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DOI：
10.1364/optica.3.000585
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发表时间：
2016-06-20
期刊：
影响因子：
10.4
通讯作者：
Bahl, Gaurav
中科院分区：
文献类型：
--
作者：
Han, Kewen;Kim, JunHwan;Bahl, Gaurav
高Q光子微腔传感器使纳米粒子（如单个病毒和大分子）的无标记测量接近基本检测极限。然而，关键的科学挑战仍然存在：（1）光子不直接耦合到机械参数，如质量密度，可压缩性或粘弹性，以及（2）由于依赖于随机扩散将分析物带到传感区域，目前的技术无法测量流体样品中的所有颗粒。在这里，我们提出了一种新的，无标签的微流体光学机械传感器，解决了这两个挑战，使，第一次，快速光子传感流体中自由流动的颗粒的机械特性。传感是通过光子与远程声子的光机械耦合实现的，远程声子在设备内部深处形成了一个近乎完美的网络。我们的光-机械-流体方法能够以可能超过10，000个颗粒/秒的速率测量颗粒质量密度、机械可压缩性和粘弹性。独特的是，我们表明，这种高Q值微腔传感器的灵敏度是最高的分析物位于最远的光学模式，在该设备的中心，其中的流量是最快的。我们的研究结果使流动颗粒的流动速度与商业流式细胞术的最新不可访问的机械分析。(C)2016美国光学学会
High-Q photonic microcavity sensors have enabled the label-free measurement of nanoparticles, such as single viruses and large molecules, close to the fundamental limits of detection. However, key scientific challenges persist: (1) photons do not directly couple to mechanical parameters such as mass density, compressibility, or viscoelasticity, and (2) current techniques cannot measure all particles in a fluid sample due to the reliance on random diffusion to bring analytes to the sensing region. Here, we present a new, label-free microfluidic optomechanical sensor that addresses both challenges, enabling, for the first time, the rapid photonic sensing of the mechanical properties of freely flowing particles in a fluid. Sensing is enabled by optomechanical coupling of photons to long-range phonons that cast a near-perfect net deep inside the device. Our opto-mechano-fluidic approach enables the measurement of particle mass density, mechanical compressibility, and viscoelasticity at rates potentially exceeding 10,000 particles/second. Uniquely, we show that the sensitivity of this high-Q microcavity sensor is highest when the analytes are located furthest from the optical mode, at the center of the device, where the flow is fastest. Our results enable till-date inaccessible mechanical analysis of flowing particles at speeds comparable to commercial flow cytometry. (C) 2016 Optical Society of America