Visceral adipose tissue, a potential risk factor for carotid atherosclerosis - Results of the multicultural community health assessment trial (M-CHAT)
Visceral adipose tissue, a potential risk factor for carotid atherosclerosis - Results of the multicultural community health assessment trial (M-CHAT)
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DOI：
10.1161/strokeaha.107.484113
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发表时间：
2007-09-01
期刊：
影响因子：
8.3
通讯作者：
Mancini, G. B. John
中科院分区：
文献类型：
--
作者：
Lear, Scott A.;Humphries, Karin H.;Mancini, G. B. John
背景和目的-腹型肥胖和动脉粥样硬化之间的联系被认为是由于过多的内脏脂肪组织（VAT），这与传统的危险因素有关。我们假设VAT是动脉粥样硬化的一个独立危险因素。（原住民、中国人、欧洲人和南亚人）和体重指数范围（= 30 kg/m2）进行增值税评估（通过计算机断层扫描），颈动脉粥样硬化结果：VAT与颈动脉内膜中层厚度（IMT）、斑块面积、和总面积（IMT面积和斑块面积之和），调整了人口统计学、家族史、吸烟和男性和女性的体脂百分比。在男性中，在调整胰岛素、血糖、同型半胱氨酸、血压和血脂后，VAT与IMT和总面积相关。在进一步调整腰围或腰臀比后，这种相关性与IMT仍然显著。在妇女中，增值税不再与IMT或总面积调整后的风险factors.Conclusions-增值税是与动脉粥样硬化相关的肥胖的主要区域，并可能代表一个额外的危险因素，男性颈动脉粥样硬化。大多数但不是所有的这种风险可以通过腰围或腰臀比测量在临床上反映出来。
Background and Purpose - The association between abdominal obesity and atherosclerosis is believed to be due to excess visceral adipose tissue (VAT), which is associated with traditional risk factors. We hypothesized that VAT is an independent risk factor for atherosclerosis.Methods - Healthy men and women (N = 794) matched for ethnicity (aboriginal, Chinese, European, and South Asian) and body mass index range (= 30 kg/m(2)) were assessed for VAT (by computed tomography scan), carotid atherosclerosis (by ultrasound), total body fat, cardiovascular risk factors, lifestyle, and demographics.Results - VAT was associated with carotid intima-media thickness (IMT), plaque area, and total area (IMT area and plaque area combined) after adjusting for demographics, family history, smoking, and percent body fat in men and women. In men, VAT was associated with IMT and total area after adjusting for insulin, glucose, homocysteine, blood pressure, and lipids. This association remained significant with IMT after further adjustment for either waist circumference or the waist-to-hip ratio. In women, VAT was no longer associated with IMT or total area after adjusting for risk factors.Conclusions - VAT is the primary region of adiposity associated with atherosclerosis and likely represents an additional risk factor for carotid atherosclerosis in men. Most but not all of this risk can be reflected clinically by either the waist circumference or waist- hip ratio measures.