[Molecular mechanisms of diabetic wound healing].

[Molecular mechanisms of diabetic wound healing].
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DOI：
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发表时间：
2010-12
期刊：
Sheng li ke xue jin zhan [Progress in physiology]
影响因子：
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通讯作者：
Lu Tie;Yilixiati Xiaokaiti;Xian Wang;Alex F. Chen;Xue-jun Li
Lu Tie;Yilixiati Xiaokaiti;Xian Wang;Alex F. Chen;Xue-jun Li
中科院分区：
其他
文献类型：
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作者：
Lu Tie;Yilixiati Xiaokaiti;Xian Wang;Alex F. Chen;Xue-jun Li

文献摘要

相似文献

难治性伤口是糖尿病患者中导致截肢的严重并发症，也是治疗方案有限的糖尿病患者住院的主要原因。然而，其潜在的机制仍有待于充分阐明。糖尿病创面延迟愈合的原因很多，如生长因子、一氧化氮(NO)、活性氧(ROS)、基质金属蛋白酶(MMPs)、microRNA、内皮祖细胞(EPC)等。本文就糖尿病创面愈合障碍的分子机制进行综述。
Refractory wound is a severe complication that leads to limb amputation in diabetes, and is also a leading cause of hospitalizations in diabetic patients with limited treatment regimens. However, the underlying mechanisms remain to be fully elucidated. Various factors contribute to delayed diabetic wound healing, such as growth factor, nitric oxide (NO), reactive oxygen species (ROS), matrix metalloproteinases (MMPs), microRNA, endothelial progenitor cells (EPCs), etc. In this review, we will discuss the recent findings on the molecular mechanisms underlying impaired diabetic wound healing.