Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6
Bead-type polystyrene/nano-CaCO3 (PS/nCaCO3) composite: a high-performance adsorbent for the removal of interleukin-6
复制标题
珠型聚苯乙烯/纳米碳酸钙（PS/nCaCO(3)）复合材料：一种去除白细胞介素6的高性能吸附剂
DOI：
10.1039/c8tb02504e
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发表时间：
2019-03-07
影响因子：
7
通讯作者：
Li, Wenzhong
中科院分区：
文献类型：
--
作者：
Chai, Yamin;Chen, Jie;Li, Wenzhong
A novel nano-CaCO3 (nCaCO(3)) particle composite-derived polystyrene (PS) resin was successfully synthesized by a suspension polymerization method. The nCaCO(3) reinforced PS material (PS/ nCaCO(3)) possessed a structure with abundant mesopores of high porosity, high specific surface area (828.3 m(2) g(-1)) and large pore volume (1.83 cm(3) g(-1)). It was revealed that the incorporation of nCaCO(3) into the PS matrix enhanced both the mechanical strength which can prevent the fragmentation and its adsorption capacity for interleukin-6 (IL-6, MW = 24.0 kDa) from human plasma. The adsorption isotherm could be described by the Langmuir model and classified as S-3 type, showing an IL-6 uptake of up to 25.6 ng g(-1) at an equilibrium concentration of about 500 ng L-1. The adsorption capacity for IL-6 of PS/nCaCO(3) is not only significantly higher than that of PS (without nCaCO(3)), but also superior to those of currently available adsorbents that are under clinical studies (e. g., CytoSorbt towards cytokines). In addition, the PS/ nCaCO3 adsorbent also had good hemocompatibility and showed no leakage of nCaCO(3) in the plasma in a flowing model system. Therefore, the synthesized PS/nCaCO(3) nano-composite has a great potential to be used as an efficient adsorbent for the removal of interleukin-6 (IL-6) from blood of inflammatory and auto-immune disease patients through hemoperfusion.
