Regulatory T Cells and Their Prognostic Value in Hepatopancreatobiliary Tumours
Regulatory T Cells and Their Prognostic Value in Hepatopancreatobiliary Tumours
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DOI：
10.5754/hge14619
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发表时间：
2014-10-01
影响因子：
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通讯作者：
Aktas, Safiye
中科院分区：
文献类型：
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作者：
Ozgur, Halil Hakan;Ercetin, Ayse Pinar;Aktas, Safiye
背景/目标：本研究旨在探讨Foxp 3 + Treg细胞、CD 4 + T细胞和CD 8 + T细胞在胆囊癌、胰腺癌和肝癌中的预后价值。方法：胆囊癌20例，胰腺癌25例，肝癌8例。Foxp 3、CD 4和CD 8的免疫组化评价与组织病理学和临床预后参数进行了比较。结果如下：胆囊癌、胰腺癌、肝癌患者癌周Foxp 3、CD 4和CD 8表达水平均显著高于癌内表达水平（p
Background/Aims: The aim of this study was to determine the prognostic values of Foxp3+ Treg cells, CD4+ Tcells and CD8+ T cells in cancer cases of gallbladder, pancreas and liver. Methodology: This study included 20 patients with gallbladder cancer, 25 patients with pancreatic cancer and 8 patients with liver cancer. Foxp3, CD4 and CD8 were immunohistochemically evaluated and compared with histopathological and clinical prognostic parameters. Results: Foxp3, CD4 and CD8 expression levels were significantly higher in peritumoral areas than in intratumoral areas in patients with gallbladder, pancreas, liver cancers (p