Stat3: friend or foe in colitis and colitis-associated cancer?
Stat3: friend or foe in colitis and colitis-associated cancer?
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Stat3：结肠炎和结肠炎相关癌症的朋友或敌人？
DOI：
10.1097/mib.0000000000000180
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发表时间：
2014-12
影响因子：
4.9
通讯作者：
Theiss AL
中科院分区：
文献类型：
--
作者：
Han J;Theiss AL
慢性炎症使组织易于发生癌症。患有炎症性肠病的个体患结直肠癌的风险增加，这取决于疾病的严重程度，持续时间和管理。肠上皮细胞在结肠炎和结肠炎相关癌症期间表现出线粒体功能障碍。信号转导和转录激活因子（Stat）-3是一种参与促生长和抗凋亡信号通路的转录因子。除了作为转录因子的活性外，Stat 3还存在于细胞的线粒体中，在那里它是最佳电子传递链活性所必需的，并保护免受应激诱导的线粒体功能障碍。线粒体Stat 3的功能尚未完全了解;二分法的作用包括保护免受细胞损伤，但也支持恶性转化。本文综述了Stat 3在结肠炎和结直肠癌中对肠上皮细胞命运的调节作用，重点是线粒体功能障碍和线粒体Stat 3在疾病进展过程中的潜在参与。
Chronic inflammation predisposes tissue to cancer development. Individuals afflicted with inflammatory bowel diseases are at an increased risk of developing colorectal cancer depending on disease severity, duration, and management. The intestinal epithelium exhibits mitochondrial dysfunction during colitis and colitis-associated cancer. Signal Transducer and Activator of Transcription (Stat)-3 is a transcription factor involved in growth-promoting and antiapoptotic signaling pathways. In addition to its activities as a transcription factor, Stat3 resides in the mitochondria of cells where it is required for optimal electron transport chain activity and protects against stress-induced mitochondrial dysfunction. The function of mitochondrial Stat3 is not completely understood; dichotomous roles include protecting against cellular injury but also supporting malignant transformation. This review discusses the roles of Stat3 in the regulation of intestinal epithelial cell fate during colitis and colorectal cancer with an emphasis on mitochondrial dysfunction and the potential involvement of mitochondrial Stat3 during disease progression.