THE EFFECT OF ANTIBIOTICS ON AGENTS OF THE PSITTACOSISLYMPHOGRANULOMA GROUP .2. THE EFFECT OF AUREOMYCIN
THE EFFECT OF ANTIBIOTICS ON AGENTS OF THE PSITTACOSISLYMPHOGRANULOMA GROUP .2. THE EFFECT OF AUREOMYCIN
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DOI：
10.1093/infdis/87.3.264
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发表时间：
1950-01-01
影响因子：
6.4
通讯作者：
WEISS, E
中科院分区：
文献类型：
--
作者：
GOGOLAK, FM;WEISS, E
研究了金霉素对鸡胚卵黄囊中生长的猫肺炎病原体的影响，认为金霉素比青霉素更有效将反映在其对病毒生物学的影响上。关注金霉素。0.025 ~ 0.25 mg可显著延长鸡胚的寿命。死亡的延迟与数量成正比。给定，表明在鸡胚中抗生素以恒定速率被破坏。金霉素的作用与病毒无关。（从10到100,000 Ld50）和管理时间。抗生素的有效时间长达24小时。在胚胎预期死亡之前。在抗生素的作用下，机体的初始分裂被阻止，生长被大大延缓。组成团簇和囊泡的颗粒慢慢扩大，最终变成小斑块。金霉素似乎是一种比青霉素更有效的猫肺炎病毒活性抑制剂。由于它有能力阻止生长和最初的身体分裂，即使在大量的情况下，它也是有效的。有一半的宿主细胞被侵入。
Effects of aureomycin on the agent of feline pneumonitis grown in the yolk sacs of chick embryos were studied in the belief that the greater effectiveness of aureomycin over penicillin would be reflected in its influence on the biology of the virus. Aureomycin in concns. of 0.025 to 0.25 mg. significantly prolonged the life of the chick embryos. The delay of death was directly proportional to the amt. given, indicating that in the chick embryo the antibiotic was destroyed at a constant rate. The effect of aureomycin was markedly independent of virus concn. (from 10 to 100,000 Ld50) and time of admn. The antibiotic was effective up to 24 hrs. before the expected death of the embryos. Under the influence of the antibiotic, initial body division was prevented and growth was greatly retarded. The granules making up the clusters and vesicles slowly enlarged and eventually became small plaques. Aureomycin appeared to be a more powerful inhibitor of the activity of feline pneumonitis virus than penicillin. Because of its ability to prevent growth as well as initial body division, it was effective even when a large no. of host cells were invaded.