Distributed coding of actual and hypothetical outcomes in the orbital and dorsolateral prefrontal cortex.
Distributed coding of actual and hypothetical outcomes in the orbital and dorsolateral prefrontal cortex.
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DOI：
10.1016/j.neuron.2011.03.026
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发表时间：
2011-05-26
期刊：
影响因子：
16.2
通讯作者：
Lee D
中科院分区：
文献类型：
--
作者：
Abe H;Lee D
只有当这些结果可以正确地归因于特定的行为时，关于未选择行为的假设结果的知识才是有益的。在这里，我们表明，在一个模拟的石头剪刀布游戏，恒河猴可以调整他们的选择行为，根据实际和假设的结果，从他们选择和未选择的行动，分别。此外，背外侧前额叶皮层和眶额皮层的神经元在实际和假设的结果被显示给动物后立即编码了与这些结果相关的信号。此外，与眶额皮层的神经元相比，背外侧前额叶皮层的神经元更有可能根据特定行为的假设结果改变其活动。前额叶皮层对多个动作及其结果的联合和并行编码可能会提高强化学习的效率，也有助于他们的上下文相关记忆。
Knowledge about hypothetical outcomes from unchosen actions is beneficial only when such outcomes can be correctly attributed to specific actions. Here, we show that during a simulated rock-paper-scissors game, rhesus monkeys can adjust their choice behaviors according to both actual and hypothetical outcomes from their chosen and unchosen actions, respectively. In addition, neurons in both dorsolateral prefrontal cortex and orbitofrontal cortex encoded the signals related to actual and hypothetical outcomes immediately after they were revealed to the animal. Moreover, compared to the neurons in the orbitofrontal cortex, those in the dorsolateral prefrontal cortex were more likely to change their activity according to the hypothetical outcomes from specific actions. Conjunctive and parallel coding of multiple actions and their outcomes in the prefrontal cortex might enhance the efficiency of reinforcement learning and also contribute to their context-dependent memory.