Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS
Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS
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DOI：
10.1289/ehp.6845
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发表时间：
2004-06-01
影响因子：
10.4
通讯作者：
Kennedy, T
中科院分区：
文献类型：
--
作者：
Brody, JG;Aschengrau, A;Kennedy, T
农药在乳腺癌的病因学研究中引起了人们的兴趣，因为许多农药模仿雌激素（一种已知的乳腺癌危险因素），或者导致动物乳腺肿瘤，但之前的大多数研究都受到限制，因为只使用了美国长期禁用的几种农药残留的一次性组织测量。作为评估历史上禁用和当前使用的农药暴露情况的替代方法，我们使用地理信息系统 (GIS) 技术对居住在马萨诸塞州科德角的 1, 165 名妇女和 1,006 名对照组进行了一项基于人群的病例对照研究，这些妇女在 1988 年至 1995 年被诊断患有乳腺癌。我们评估了自 1948 年（当滴滴涕首次在当地使用时）用于树木害虫（例如舞毒蛾）、酸果蔓沼泽、其他农业和湿地蚊虫控制的农药的暴露情况。我们发现农药使用与乳腺癌之间没有总体关联模式。我们发现，在蔓越莓沼泽上空中喷洒持久性农药以及在树害虫或农业上喷洒持久性较低的农药，风险会略有增加。这些暴露的调整后比值比为 1.8 或更低，并且，除了少数例外，置信区间并未排除零值。这项研究受到以下因素的限制：家庭住址位置的不确定性（特别是 1980 年之前）、未记录的树虫和蚊子控制事件，以及缺乏有关研究中女性居住在科德角附近的年份的暴露信息，以及缺乏有关在科德角有潜在重要生命早期接触史的女性的信息，这些女性因搬走而没有被包括在内。
Pesticides are of interest in etiologic studies of breast cancer because many mimic estrogen, a known breast cancer risk factor, or cause mammary tumors in animals, but most previous studies have been limited by using one-time tissue measurements of residues of only a few pesticides long banned in the United States. As an alternative method to assess historical exposures to banned and current-use pesticides, we used geographic information system (GIS) technology in a population-based case-control study of 1, 165 women residing in Cape Cod, Massachusetts, who were diagnosed with breast cancer in 1988-1995 and 1,006 controls. We assessed exposures dating back to 1948 (when DDT was first used there) from pesticides applied for tree pests (e.g., gypsy moths), cranberry bogs, other agriculture, and mosquito control on wetlands. We found no overall pattern of association between pesticide use and breast cancer. We found modest increases in risk associated with aerial application of persistent pesticides on cranberry bogs and less persistent pesticides applied for tree pests or agriculture. Adjusted odds ratios for these exposures were 1.8 or lower, and, with a few exceptions, confidence intervals did not exclude the null. The study is limited by uncertainty about locations of home addresses (particularly before 1980) and unrecorded tree pest and mosquito control events as well as lack of information about exposures during years when women in the study lived off Cape Cod and about women with potentially important early life exposures on Cape Cod who were not included because they moved away.