Nuclear organization of cholinergic, putative catecholaminergic and serotonergic systems in the brains of two megachiropteran species
Nuclear organization of cholinergic, putative catecholaminergic and serotonergic systems in the brains of two megachiropteran species
复制标题
DOI：
10.1016/j.jchemneu.2010.05.008
复制
发表时间：
2010-10-01
影响因子：
2.8
通讯作者：
Manger, Paul R.
中科院分区：
文献类型：
--
作者：
Dell, Leigh-Anne;Kruger, Jean-Leigh;Manger, Paul R.
核组织的胆碱能，推定的儿茶酚胺和胆碱能系统内的大脑的megachiropteran稻草色果蝠（Eidolon helvum）和Wahlberg的肩章果蝠（Epomophorus wahlbergi）的胆碱乙酰转移酶，酪氨酸羟化酶和5-羟色胺的免疫组织化学。本研究的目的是调查这些物种的神经调节系统的核补体可能存在的差异相比，以前的研究megachiropterans，microchiropterans和其他哺乳动物。这些系统的核组织与之前描述的巨手类动物相同，并且与其他哺乳动物物种，特别是灵长类动物显示出许多相似之处;例如，两个物种中假定的儿茶酚胺能系统在蓝斑（A6 c）内呈现出非常紧凑的核，这仅在巨手类动物和灵长类动物中发现。对38种哺乳动物和82个来自这些系统的特征进行的支序分析表明，megachiropterans与灵长类动物形成了一个姐妹群，排除了其他哺乳动物，包括microchiropterans。此外，结果表明，megachiropterans和microchiropterans没有明确的系统发育关系，彼此，microchiropteran系统是最密切的食虫动物。因此，目前的神经研究结果支持翼手目的二系起源。(C)2010 Elsevier B. V.保留所有权利。
The nuclear organization of the cholinergic, putative catecholaminergic and serotonergic systems within the brains of the megachiropteran straw-coloured fruit bat (Eidolon helvum) and Wahlberg's epauletted fruit bat (Epomophorus wahlbergi) were identified following immunohistochemistry for cholineacetyltransferase, tyrosine hydroxylase and serotonin. The aim of the present study was to investigate possible differences in the nuclear complement of the neuromodulatory systems of these species in comparison to previous studies on megachiropterans, microchiropterans and other mammals. The nuclear organization of these systems is identical to that described previously for megachiropterans and shows many similarities to other mammalian species, especially primates; for example, the putative catecholaminergic system in both species presented a very compact nucleus within the locus coeruleus (A6c) which is found only in megachiropterans and primates. A cladistic analysis of 38 mammalian species and 82 characters from these systems show that megachiropterans form a sister group with primates to the exclusion of other mammals, including microchiropterans. Moreover, the results indicate that megachiropterans and microchiropterans have no clear phylogenetic relationship to each other, as the microchiropteran systems are most closely associated with insectivores. Thus a diphyletic origin of Chiroptera is supported by the present neural findings. (C) 2010 Elsevier B.V. All rights reserved.