Odontogenic ghost cell carcinoma: report of four new cases and review of the literature.
Odontogenic ghost cell carcinoma: report of four new cases and review of the literature.
复制标题
牙源性鬼细胞癌：四例新病例报告及文献复习。
DOI：
10.1111/j.1600-0714.1999.tb02048.x
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
R. Jordan
中科院分区：
文献类型：
--
作者：
Yong Lu;D. Mock;D. Mock;T. Takata;R. Jordan
迄今为止，在英语文献中仅报道了12例牙源性鬼影细胞癌（OGCC）。这篇文章报告了四个额外的情况下，这种罕见的牙源性肿瘤，并检查了他们与那些以前描述。从已发表病例的数量来看，OGCC在亚洲人中比其他种族更普遍，在上颌骨比下颌骨更常见，男性比女性更常见。组织学上，良性钙化牙源性囊肿（COC）的成分可以在所有恶性变异体中被识别出来，无论是单独的还是与恶性上皮成分混合的。后者可以由小的基底细胞或大的上皮细胞组成。尽管有不同的组织学表现，但肿瘤的生物学行为是不可预测的，一些病例的特点是相对缓慢的生长，而另一些病例的特点是局部侵袭性和潜在的致命过程。该肿瘤显然最常由先前存在的良性COC的恶性转化而产生，尽管它也可能由其他牙源性肿瘤发展而来。
Only 12 odontogenic ghost cell carcinomas (OGCC) have been reported in the English language literature to date. This article reports four additional cases of this rare odontogenic tumour and examines them in relation to those previously described. Judging from the number of published cases, the OGCC is more prevalent in Asians than other racial groups, occurs more often in the maxilla than the mandible, and is slightly more common in males than females. Histologically, elements of a benign calcifying odontogenic cyst (COC) can be identified in all the malignant variants, either separated or admixed with the malignant epithelial component. The latter can consist of either small basaloid cells or large epithelial cells. Despite the differing histological presentations, the biological behavior of the tumour is unpredictable, with some cases characterized by relatively indolent growth and others by a locally aggressive and potentially fatal course. The tumour apparently arises most often from malignant transformation of a preexisting benign COC, although it may also develop from other odontogenic tumours.