Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails
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DOI：
10.1136/annrheumdis-2011-200478
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发表时间：
2012-04-01
影响因子：
27.4
通讯作者：
Aydin, Sibel Z.
中科院分区：
文献类型：
--
作者：
Ash, Zoe R.;Tinazzi, Ilaria;Aydin, Sibel Z.
目的终末期病变是银屑病关节炎(PSA)的一个主要特征，影像研究也支持这一点。鉴于指甲疾病通常先于PSA，并且指甲直接锚定在指甲凹陷上，作者询问指甲参与银屑病是否等同于系统性终末期疾病。方法46例银屑病患者(31例有指甲疾病)和21例匹配的健康对照(HC)被纳入研究对象。结果银屑病患者的股骨头炎症评分明显高于对照组(中位数分别为21(0~65)分和11(3~39分)，P=0.005)。有甲病组(23分，0~65分)高于无甲病组(15分，5~26分，P=0.02)和无甲病组(11分，3~39分，P=0.003)。有甲病患者的炎症评分(13分，0-34分)高于无甲病患者(8分，2-15分，p=0.02)和无甲病患者(5分(0-19分)，p=0.02)。
Objective Enthesopathy is a major feature of psoriatic arthritis (PsA), which is supported by imaging studies. Given that nail disease often predates PsA and that the nail is directly anchored to entheses, the authors asked whether nail involvement in psoriasis equates with a systemic enthesopathy.Methods Forty-six patients with psoriasis (31 with nail disease) and 21 matched healthy controls (HC) were recruited. 804 entheses of upper and lower limbs were scanned by an ultrasonographer blinded to clinical details.Results Psoriasis patients had higher enthesitis scores than HC (median (range) 21 (0-65) vs 11 (3-39), p=0.005). Enthesopathy scores were higher in patients with nail disease (23 (0-65)) than in patients without nail disease (15 (5-26), p=0.02) and HC (11 (3-39), p=0.003). Inflammation scores of patients with nail disease (13 (0-34)) were higher than patients without nail disease (8 (2-15), p=0.02) and HC (5 (0-19), p