US National Institutes of Health Prioritization of SARS-CoV-2 Variants.
US National Institutes of Health Prioritization of SARS-CoV-2 Variants.
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DOI：
10.3201/eid2905.221646
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发表时间：
2023-05
影响因子：
11.8
通讯作者：
Smith, Derek J.
中科院分区：
文献类型：
--
作者：
Turner, Sam;Alisoltani, Arghavan;Bratt, Debbie;Cohen-Lavi, Liel;Dearlove, Bethany L.;Drosten, Christian;Fischer, Will M.;Fouchier, Ron A. M.;Gonzalez-Reiche, Ana Silvia;Jaroszewski, Lukasz;Khalil, Zain;LeGresley, Eric;Johnson, Marc;Jones, Terry C.;Muehlemann, Barbara;O'Connor, David;Sedova, Mayya;Shukla, Maulik;Theiler, James;Wallace, Zachary S.;Yoon, Hyejin;Zhang, Yun;van Bakel, Harm;Degrace, Marciela M.;Ghedin, Elodie;Godzik, Adam;Hertz, Tomer;Korber, Bette;Lemieux, Jacob;Niewiadomska, Anna M.;Post, Diane J.;Rolland, Morgane;Scheuermann, Richard;Smith, Derek J.
自2020年底以来，SARS-CoV-2变异株经常出现，与先前流行的毒株存在竞争性和表型差异，有时可能会逃避先前暴露和感染产生的免疫力。早期检测小组是美国国立卫生研究院国家过敏和传染病研究所SARS-CoV-2病毒进化评估计划的组成小组之一。该小组使用生物信息学方法来监测新兴和循环菌株的出现，传播和潜在的表型特性，以确定该计划中实验组的最相关变体，以进行表型表征。自二零二一年四月起，本集团每月对变体进行优先排序。优先化的成功包括快速识别SARS-CoV-2的大多数主要变体，并为美国国立卫生研究院计划内的实验组提供容易获得的关于SARS-CoV-2的最新进化和流行病学的定期更新信息，这些信息可用于指导表型研究。
Since late 2020, SARS-CoV-2 variants have regularly emerged with competitive and phenotypic differences from previously circulating strains, sometimes with the potential to escape from immunity produced by prior exposure and infection. The Early Detection group is one of the constituent groups of the US National Institutes of Health National Institute of Allergy and Infectious Diseases SARS-CoV-2 Assessment of Viral Evolution program. The group uses bioinformatic methods to monitor the emergence, spread, and potential phenotypic properties of emerging and circulating strains to identify the most relevant variants for experimental groups within the program to phenotypically characterize. Since April 2021, the group has prioritized variants monthly. Prioritization successes include rapidly identifying most major variants of SARS-CoV-2 and providing experimental groups within the National Institutes of Health program easy access to regularly updated information on the recent evolution and epidemiology of SARS-CoV-2 that can be used to guide phenotypic investigations.
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