CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure.
CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure.
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DOI：
10.1186/s13059-023-03088-4
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发表时间：
2023-10-30
期刊：
影响因子：
12.3
通讯作者：
Pertea, Mihaela
中科院分区：
文献类型：
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作者：
Varabyou, Ales;Sommer, Markus J;Erdogdu, Beril;Shinder, Ida;Minkin, Ilia;Chao, Kuan-Hao;Park, Sukhwan;Heinz, Jakob;Pockrandt, Christopher;Shumate, Alaina;Rincon, Natalia;Puiu, Daniela;Steinegger, Martin;Salzberg, Steven L;Pertea, Mihaela
CHESS 3代表了基于54个身体部位近10,000个RNA-seq实验的改进的人类基因目录。它通过整合最新的参考数据和算法、用于噪声过滤的机器学习技术和新的蛋白质结构预测方法，显著改善了当前的基因组注释。CHESS 3包含41,356个基因，其中蛋白编码基因19,839个，转录本158,377个，其中14863个蛋白编码转录本不在其他目录中。它包括所有的MANE转录本以及大多数RefSeq和GENCODE基因的至少一个转录本。在CHM13人类基因组上，CHESS 3目录包含另外129个蛋白质编码基因。国际象棋3可在http://ccb.jhu.edu/chess。在线版本包含补充资料，下载地址：10.1186/s13059-023-03088-4。
CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq experiments across 54 body sites. It significantly improves current genome annotation by integrating the latest reference data and algorithms, machine learning techniques for noise filtering, and new protein structure prediction methods. CHESS 3 contains 41,356 genes, including 19,839 protein-coding genes and 158,377 transcripts, with 14,863 protein-coding transcripts not in other catalogs. It includes all MANE transcripts and at least one transcript for most RefSeq and GENCODE genes. On the CHM13 human genome, the CHESS 3 catalog contains an additional 129 protein-coding genes. CHESS 3 is available at http://ccb.jhu.edu/chess. The online version contains supplementary material available at 10.1186/s13059-023-03088-4.