Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness.
Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness.
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DOI：
10.1155/2016/5460732
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发表时间：
2016
影响因子：
3.1
通讯作者：
Yuan LL
中科院分区：
文献类型：
--
作者：
Duric V;Clayton S;Leong ML;Yuan LL
神经精神症状和精神疾病常见于慢性全身性疾病患者。高达 50% 的患者存在抑郁等情绪障碍，导致身体恢复受损，治疗方案也更加复杂。与全身性疾病的身体和情感方面相关的压力被认为会引起有害影响，引发共病精神障碍。然而，临床报告还表明，全身性疾病和精神疾病之间的关系是双向的，进一步增加了潜在病理生理过程的复杂性。在这篇综述中，我们讨论了将慢性压力与全身性疾病联系起来的最新证据，例如免疫反应系统的激活和常见促炎介质的释放。总而言之，需要发现新的靶点，以开发更好的治疗压力相关精神疾病的方法，并改善不同全身性疾病的心理健康方面。
Neuropsychiatric symptoms and mental illness are commonly present in patients with chronic systemic diseases. Mood disorders, such as depression, are present in up to 50% of these patients, resulting in impaired physical recovery and more intricate treatment regimen. Stress associated with both physical and emotional aspects of systemic illness is thought to elicit detrimental effects to initiate comorbid mental disorders. However, clinical reports also indicate that the relationship between systemic and psychiatric illnesses is bidirectional, further increasing the complexity of the underlying pathophysiological processes. In this review, we discuss the recent evidence linking chronic stress and systemic illness, such as activation of the immune response system and release of common proinflammatory mediators. Altogether, discovery of new targets is needed for development of better treatments for stress-related psychiatric illnesses as well as improvement of mental health aspects of different systemic diseases.