Leukotriene B4 and platelet-activating factor in human skin
Leukotriene B4 and platelet-activating factor in human skin
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人体皮肤中的白三烯 B4 和血小板激活因子
DOI：
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发表时间：
2004
影响因子：
3
通讯作者：
L. Dubertret
中科院分区：
文献类型：
--
作者：
L. Michel;L. Dubertret
急性炎症反应的特征是白细胞浸润，伴有血管通透性和局部血流增加。白细胞浸润可由趋化因子如白三烯B4（LTB4）和PAF-乙酸（以前称为血小板活化因子）诱导，这些因子可在炎性病变中产生。血管渗透性和血流量的增加也受到LTB4和paf-acether以及其他几种物质的影响，包括组胺和甘草素。LTB4通过5脂氧合酶途径衍生自花生四烯酸，是已知最有效的白细胞趋化物质之一。在动物模型和人类中，LTB4的皮内注射诱导真皮中性粒细胞浸润。局部应用LTB4到人皮肤诱导含有大量完整中性粒细胞的表皮内微膨胀。已发现LTB4在银屑病皮损中增加，但其由表皮细胞合成仍不确定。像其他白三烯一样，LTB4可以刺激培养的人表皮角质形成细胞的DNA合成。然而，在培养的人角质形成细胞上发现了LTC4的受体，但未发现LTB4的受体。PAF-乙酸酯是一种醚连接磷脂，被鉴定为1-O-烷基-2-O-乙酰基-sn-甘油-3-磷酸胆碱，被认为是急性过敏和炎症反应的最有效介质之一。例如，皮内注射帕法乙醚可诱导炎症事件，如中性粒细胞浸润和血管通透性增加。最近的数据表明，皮肤细胞，如成纤维细胞和角质形成细胞，能够产生血小板活化因子，并在过敏性皮肤反应的发展过程中释放。在银屑病皮损中，paf也增加了，这很容易使人推测paf可能促进了各种皮肤疾病的发展，包括急性和慢性皮肤炎症。在未来，LTB4和PAF拮抗剂可能有助于回答这两种介质可能在许多慢性炎症性皮肤病中起关键作用的假设，并可能为局部和全身治疗提供新的前景。
SummaryAcute inflammatory reactions are characterized by leukocyte infiltration associated with increases in vascular permeability and in local blood flow. Leukocyte infiltration can be induced by chemotactic factors such as leukotriene B4 (LTB4) and paf-acether (formely known as platelet-activating factor) that can be generated within inflammatory lesions. Vascular permeability and increase in blood flow are also affected by LTB4 and paf-acether, as well as by several other substances, including histamine and prostaglandins. Derived from arachidonic acid via the 5 lipo-oxygenase pathway, LTB4 is one of the most potent leukocyte chemotactic substances known. Intradermal injections of LTB4 induce dermal neutrophil infiltration in animal models and in humans. Topical application of LTB4 to human skin induces intraepidermal micro-abscesses containing numerous intact neutrophils. LTB4 has been found to be increased in psoriatic lesions, but its synthesis by epidermal cells remains undecided. Like other leukotrienes, LTB4 can stimulate DNA synthesis in cultured human epidermal keratinocytes. However, receptors for LTC4 but not for LTB4 have been found on human keratinocytes in culture. Paf-acether is an ether-linked phospholipid identified as 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and is considered to be one of the most potent mediators of acute allergic and inflammatory reactions. For instance, intradermal injection of pafacether induces inflammatory events such as neutrophil infiltration and increase in vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, are capable of producing paf and that paf is released during the development of allergic cutaneous reactions. Paf is also increased in psoriatic lesions, and it is tempting to speculate that paf may contribute to the development of various skin disorders with acute and chronic skin inflammation. In the future, LTB4 and paf antagonists might help in providing an answer to the hypothesis that these two mediators may have a key role in many chronic inflammatory skin diseases and may offer new prospects for topical and systemic treatments.
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Omega 氧化是人多形核白细胞中白三烯 B4 分解代谢的主要途径。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shak,S;Goldstein,IM
通讯作者：
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发表时间：
1982
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/s0006-291x(05)81261-6
发表时间：
1991
影响因子：
3.1
作者：
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通讯作者：
Cochrane,CG
用 IL-1-β、肿瘤坏死因子或 IFN-γ 刺激的人单核细胞合成双相血小板激活因子。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Valone,FH;Epstein,LB
通讯作者：
Epstein,LB
啮齿动物和人类表皮中白三烯 B4 的细胞色素 P-450 依赖性 omega 氧化。
DOI：
10.1111/1523-1747.ep12277578
发表时间：
1989
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Mukhtar,H;Bik,DP;Ruzicka,T;Merk,HF;Bickers,DR
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Bickers,DR