RNA Viruses: ROS-Mediated Cell Death.
RNA Viruses: ROS-Mediated Cell Death.
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DOI：
10.1155/2014/467452
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发表时间：
2014
影响因子：
--
通讯作者：
Hong JR
中科院分区：
文献类型：
--
作者：
Reshi ML;Su YC;Hong JR
众所周知，活性氧（ROS）既有益又有害。本文综述了活性氧在核糖核酸（RNA）病毒致病机制中的作用。在过去的十年中，大量证据表明，感染RNA病毒的患者处于慢性氧化应激状态。在RNA病毒感染患者的各种组织中，已经报道了与SOD、抗坏血酸、硒、类胡萝卜素和谷胱甘肽相关的身体抗氧化防御系统的变化。本文综述了RNA病毒和逆转录病毒，特别关注人类流感病毒、丙型肝炎病毒（HCV）、人类免疫缺陷病毒（HIV）和水生Betanodavirus。经由RNA病毒感染的氧化应激可促成病毒性疾病发病机制的若干方面，包括细胞凋亡、免疫功能丧失、病毒复制、炎症反应和体重减轻。我们专注于如何ROS生产与宿主细胞死亡。此外，ROS可能作为信号分子在调节病毒复制和细胞器功能中发挥重要作用，可能为预防和治疗RNA病毒和逆转录病毒感染提供新的见解。
Reactive oxygen species (ROS) are well known for being both beneficial and deleterious. The main thrust of this review is to investigate the role of ROS in ribonucleic acid (RNA) virus pathogenesis. Much evidences has accumulated over the past decade, suggesting that patients infected with RNA viruses are under chronic oxidative stress. Changes to the body's antioxidant defense system, in relation to SOD, ascorbic acid, selenium, carotenoids, and glutathione, have been reported in various tissues of RNA-virus infected patients. This review focuses on RNA viruses and retroviruses, giving particular attention to the human influenza virus, Hepatitis c virus (HCV), human immunodeficiency virus (HIV), and the aquatic Betanodavirus. Oxidative stress via RNA virus infections can contribute to several aspects of viral disease pathogenesis including apoptosis, loss of immune function, viral replication, inflammatory response, and loss of body weight. We focus on how ROS production is correlated with host cell death. Moreover, ROS may play an important role as a signal molecule in the regulation of viral replication and organelle function, potentially providing new insights in the prevention and treatment of RNA viruses and retrovirus infections.