Two modes of radial migration in early development of the cerebral cortex
Two modes of radial migration in early development of the cerebral cortex
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DOI：
10.1038/83967
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发表时间：
2001-02-01
影响因子：
25
通讯作者：
Pearlman, AL
中科院分区：
文献类型：
--
作者：
Nadarajah, B;Brunstrom, JE;Pearlman, AL
发育中的大脑皮层层的形成需要神经元从它们的起源位置移动到它们的最终层位置。我们证明，使用急性皮层切片的延时成像，两种不同形式的细胞运动，运动和染色体易位，负责皮层神经元的径向迁移。这些模式的区别在于它们的动态特性和形态特征。运动和易位不是细胞类型特异性的;虽然在早期，一些细胞可能只通过易位运动，但是一旦它们的前导过程到达边缘区，易位细胞也会易位。两种放射状迁移模式的存在可以解释某些基因突变对皮质发育的不同影响。
Layer formation in the developing cerebral cortex requires the movement of neurons from their site of origin to their final laminar position. We demonstrate, using time-lapse imaging of acute cortical slices, that two distinct forms of cell movement, locomotion and somal translocation, are responsible for the radial migration of cortical neurons. These modes are distinguished by their dynamic properties and morphological features. Locomotion and translocation are not cell-type specific; although at early ages some cells may move by translocation only, locomoting cells also translocate once their leading process reaches the marginal zone. The existence of two modes of radial migration may account for the differential effects of certain genetic mutations on cortical development.