The Oxidative Metabolism of α-Chlorohydrin in the Male Rat and the Formation of Spermatocoeles
The Oxidative Metabolism of α-Chlorohydrin in the Male Rat and the Formation of Spermatocoeles
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雄性大鼠α-氯醇的氧化代谢与精囊的形成
DOI：
10.3109/00498257809061257
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发表时间：
1978
期刊：
影响因子：
1.8
通讯作者：
C. Murcott
中科院分区：
文献类型：
--
作者：
A. Jones;D. Milton;C. Murcott
1. 研究了[3-36Cl]氯丙烷-1,2-二醇（α-氯丙烷，I）在雄性大鼠体内的氧化代谢。分离得到两种代谢物，鉴定为β-氯乳酸（IV）和草酸(V)。α-氯丙烷和β-氯乳酸均未在任何组织中富集。在给药后4小时内，在尿液中检测到中间代谢物β-氯醛（III）的痕迹。体外研究表明，其代谢途径为：α-氯丙烷、β-氯醛、β-氯乳酸。对36Cl-和14C-β-氯乳酸代谢的比较研究表明，草酸盐生成缓慢，作为草酸钙引起肾小球肾炎。这种病理状况是α-氯丙烷和β-氯乳酸的利尿作用的原因，并且在高剂量时，也是其毒性的原因。草酸盐作为α-氯丙烷和一些相关化合物的代谢物，在雄性大鼠生殖系统中诱导精囊形成的作用。
1. The oxidative metabolism of [3-36Cl]chloropropan-1,2-diol (α-chloro-hydrin, I) was studied in male rats. Two metabolites were isolated and identified as β-chlorolactic acid (IV) and oxalic acid (V).2. Neither α-chlorohydrin nor β-chlorolactate was concentrated in any tissue. Traces of an intermediate metabolite, β-chlorolactaldehyde (III) were detected in the urine within 4 h of administration. Studies in vitro indicated that the metabolic pathway is: α-chlorohydrin, β-chlorolactaldehyde, β-chlorolactic acid.3. A comparative study of the metabolism of 36Cl- and 14C-β-chlorolactate showed that oxalate was produced slowly and, as calcium oxalate, caused a type of renal glomerular nephritis. This pathological condition is responsible for the diuretic action of both α-chlorohydrin and β-chlorolactate and, in higher doses, for their toxicities.4. The role of oxalate, as a metabolite of α-chlorohydrin and of a number of related compounds, in inducing the formation of spermatocoeles in the male rat reproducti...