Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
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DOI：
10.1136/jnnp.71.4.441
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发表时间：
2001-10-01
影响因子：
11
通讯作者：
Weiner, MW
中科院分区：
文献类型：
--
作者：
Du, AT;Schuff, N;Weiner, MW
Objectives-To explore volume changes of endorhinal cortex（ERC）and hippocampus in mild cognitive impairment（MCI）and Alzheimer's disease（AD）compared with normal cognition（NC）; to determine the power of the ERC and the hippocampus for discrimination between these groups. Methods-This study includes 40 subjects with NC，36 patients with MCI，and 29 patients with AD.根据冠状位TI加权MR图像手动测量ERC和海马的宽度。结果：MCI组ERC和海马体积均减小（ERC 13%，海马11%，P
Objectives-To explore volume changes of the entorhinal cortex (ERC) and hippocampus in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal cognition (NC); to determine the powers of the ERC and the hippocampus for discrimination between these groups.Methods-This study included 40 subjects with NC, 36 patients with MCI, and 29 patients with AD. Volumes of the ERC and hippocampus were manually measured based on coronal TI weighted MR images. Global cerebral changes were assessed using semiautomatic image segmentation.Results-Both ERC and hippocampal volumes were reduced in MCI (ERC 13%, hippocampus 11%, p