Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
复制标题
DOI：
10.1016/j.cell.2020.04.026
复制
发表时间：
2020-05-28
期刊：
影响因子：
64.5
通讯作者：
tenOever, Benjamin R.
中科院分区：
文献类型：
--
作者：
Blanco-Melo, Daniel;Nilsson-Payant, Benjamin E.;tenOever, Benjamin R.
病毒大流行，如SARS-CoV-2引起的大流行，对人类构成迫在眉睫的威胁。由于其最近出现，有一个关于病毒的行为和宿主反应的信息缺乏SARS-CoV-2感染。在这里，我们提供了一个深入的分析，转录响应SARS-CoV-2相比，其他呼吸道病毒。SARS-CoV-2感染的细胞和动物模型，以及COVID-19患者的转录和血清谱分析，一致揭示了独特和不适当的炎症反应。这种反应是由低水平的I型和III型干扰素与升高的趋化因子和IL-6的高表达并列定义的。我们认为，先天性抗病毒防御能力下降加上炎性细胞因子产生旺盛是COVID-19的定义和驱动特征。
Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. Wepropose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.