The Therapeutic Effect of OK-432 (Picibanil) Sclerotherapy for Benign Neck Cysts
The Therapeutic Effect of OK-432 (Picibanil) Sclerotherapy for Benign Neck Cysts
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DOI：
10.1097/mlg.0b013e3181864acf
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发表时间：
2008-12-01
期刊：
影响因子：
2.6
通讯作者：
Yeo, Seung Geun
中科院分区：
文献类型：
--
作者：
Kim, Myung Gu;Kim, Sun Gon;Yeo, Seung Geun
Background and Objectives: In general, benign neck cysts are treated by surgical excision. This can present technical difficulties and frequent recurrences, because of insufficient surgery. Sclerosing agents such as OK-432 have been tested for the nonsurgical treatment of these cysts. We have assessed the efficacy of OK-432 sclerotherapy for benign neck cysts.Materials and Methods: The study group consisted of 75 patients (42 men, 33 women) diagnosed with and treated for benign neck cysts between March 2001 and December 2007 by intralesional injection of OK-432. The liquid content of each cyst was aspirated as much as possible, and the same volume of OK-432 solution was injected. Patients were assessed by ultrasonography or computerized tomography, and therapeutic outcomes and adverse effects were evaluated by patient age, sex, cyst type, and number of injections.Results: Of the 75 treated patients, 31 (41.3%) showed total shrinkage, seven (9.3%) showed near-total shrinkage (> 90% of cyst volume), five (6.6%) showed marked shrinkage (> 70% of cyst volume), and 17 (22.7%) showed partial shrinkage (< 70% of cyst volume). No response was seen in 15 patients (20%). Despite repeated sclerotherapy, eight patients (10.7%) showed recurrences. Minor adverse effects of therapy included fever, localized pain, and odynophagia but these complications spontaneously disappeared within several days.Conclusions: OK-432 sclerotherapy is a safe and effective primary alternative to surgery in patients with benign neck cysts.
