Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy
Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy
复制标题
DOI：
10.1002/adfm.201201663
复制
发表时间：
2013-02-18
影响因子：
19
通讯作者：
Dai, Zhifei
中科院分区：
文献类型：
--
作者：
Ma, Yan;Liang, Xiaolong;Dai, Zhifei
基于负载阿霉素、Fe3O4磁性纳米颗粒和金纳米壳（cdf - au壳纳米胶束）的胆固醇基琥珀基硅烷（CSS）纳米胶束，开发了一种新型多功能给药平台，将磁共振成像、磁靶向给药、光触发药物释放和光热疗法结合起来。在金纳米壳形成后，纳米胶束的药物包封效率和负载水平均有所提高，并且对磁场有良好的响应。观察到cdf - au壳纳米胶束的t2加权磁共振成像增强。这些纳米胶束在近红外（NIR）区域显示出表面等离子体吸光度，因此由于CSS纳米胶束的独特特性，表现出近红外（808 nm）诱导的温度升高和近红外光触发的阿霉素逐步释放行为。体外光热细胞毒性实验证实，cdf - au壳纳米胶束仅在近红外激光照射下通过光热效应导致细胞死亡。用cdf - au壳纳米胶束孵育的癌细胞仅在近红外照射和磁场存在下才显示出细胞活力的显着下降，这归因于磁场引导药物传递和光热疗法的协同作用。因此，这种多组分纳米胶束可以作为一种智能的、有前途的纳米系统来开发，它集成了多种有效的癌症诊断和治疗能力。
A novel multifunctional drug-delivery platform is developed based on cholesteryl succinyl silane (CSS) nanomicelles loaded with doxorubicin, Fe3O4 magnetic nanoparticles, and gold nanoshells (CDF-Au-shell nanomicelles) to combine magnetic resonance (MR) imaging, magnetic-targeted drug delivery, light-triggered drug release, and photothermal therapy. The nanomicelles show improved drug-encapsulation efficiency and loading level, and a good response to magnetic fields, even after the formation of the gold nanoshell. An enhancement for T2-weighted MR imaging is observed for the CDF-Au-shell nanomicelles. These nanomicelles display surface plasmon absorbance in the near-infrared (NIR) region, thus exhibiting an NIR (808 nm)-induced temperature elevation and an NIR light-triggered and stepwise release behavior of doxorubicin due to the unique characteristics of the CSS nanomicelles. Photothermal cytotoxicity in vitro confirms that the CDF-Au-shell nanomicelles cause cell death through photothermal effects only under NIR laser irradiation. Cancer cells incubated with CDF-Au-shell nanomicelles show a significant decrease in cell viability only in the presence of both NIR irradiation and a magnetic field, which is attributed to the synergetic effects of the magnetic-field-guided drug delivery and the photothermal therapy. Therefore, such multicomponent nanomicelles can be developed as a smart and promising nanosystem that integrates multiple capabilities for effective cancer diagnosis and therapy.