Female predominance in meningiomas can not be explained by differences in progesterone, estrogen, or androgen receptor expression
Female predominance in meningiomas can not be explained by differences in progesterone, estrogen, or androgen receptor expression
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DOI：
10.1007/s11060-006-9146-9
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发表时间：
2006-10-01
影响因子：
3.9
通讯作者：
Haapasalo, Hannu
中科院分区：
文献类型：
--
作者：
Korhonen, Katariina;Salminen, Tiina;Haapasalo, Hannu
女性在脑膜瘤发病率和脑膜瘤和乳腺癌之间的关联优势表明，脑膜瘤的生长是依赖性的。关于性激素对脑膜瘤增殖的影响，文献中存在一些分歧。本研究旨在评估脑膜瘤的激素受体状态，并评估其与年龄、性别、组织学分级、复发和增殖活性的关系。该材料基于1989-1999年坦佩雷大学医院脑膜瘤手术的连续患者。用特异性单克隆抗体免疫组化法研究了原发性和复发性脑膜瘤中孕激素、雌激素和雄激素受体的表达。在510个肿瘤样本中测定激素状态。443例来自原发性脑膜瘤，67例来自复发性肿瘤。在这些样本中，455例为良性（WHO I级），49例为非典型（II级），6例为恶性（III级）。在原发性肿瘤样本中，88%孕激素受体阳性，40%雌激素受体阳性，39%雄激素受体阳性。I级脑膜瘤雌激素和雄激素受体的发生率明显高于高级别脑膜瘤。雌激素阳性的肿瘤样品比雌激素阴性的样品具有显著更高的增殖指数。性激素受体的表达没有性别或年龄组的差异。雌激素和雄激素受体对脑膜瘤发病机制的影响可能比以前认为的更大。女性脑膜瘤的高发病率不能用性激素受体表达的差异来解释。
The female predominance in meningioma incidence and association between meningioma and breast cancer suggest that growth of meningiomas is hormone-dependent. There are several discrepancies in literature about the proliferative effect of sex hormones on meningiomas. This study aims to evaluate the hormone receptor status of meningiomas and assess its relation to age, sex, histological grade, recurrence, and proliferation activity. The material was based on consecutive patients operated for meningioma at Tampere University Hospital in 1989-1999. The occurrence of progesterone, estrogen and androgen receptor in patients with primary and recurrent meningiomas was studied immunohistochemically by using specific monoclonal antibodies. Hormonal status was determined in 510 tumor samples. 443 samples were from primary meningiomas and 67 from recurrent tumors. Of the samples, 455 were benign (WHO grade I), 49 atypical (grade II), and 6 malignant (grade III). Of the primary tumor samples, 88% were progesterone receptor positive, 40% were positive for estrogen and 39% for androgen receptors. Grade I meningiomas had significantly higher incidence for estrogen and androgen receptors than higher grade meningiomas. Estrogen positive tumor samples had significantly higher proliferation index than estrogen negative samples. No difference in expression of sex hormone receptors was observed by sexes or age group. Estrogen and androgen receptors may have more influence on the pathogenesis of meningiomas than earlier thought. The higher incidence of meningiomas in women can not be explained by differences of sex hormone receptor expression.