Biological activities of Prunella vulgaris extract
Biological activities of Prunella vulgaris extract
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DOI：
10.1002/ptr.1324
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发表时间：
2003-11-01
影响因子：
7.2
通讯作者：
Ulrichová, J
中科院分区：
文献类型：
--
作者：
Psotová, J;Kolár, M;Ulrichová, J
发现Prunella vulgaris（总提取物）的有机部分（25.7% w/w的迷迭香酸）具有以下作用：清除二苯基苦酰肼自由基（DPPH），抑制体外人LDL Cu（II）介导的氧化，保护暴露于过氧化叔丁基或Cu（11）和Fe（111）离子的大鼠线粒体和大鼠肝细胞。OF还显示出抑制大鼠红细胞溶血的潜力，它减少了牛PMNL中由5-脂氧合酶途径产生的LTB4的产生。其他观察结果包括对HaCaT细胞和小鼠表皮成纤维细胞的抗增殖作用，以及对革兰氏阳性细菌的适度抗菌活性。迷迭香、咖啡和3-（3,4-二羟基苯基）乳酸在所有生物测定中表现出比植物提取物更弱的活性。其抗氧化、抗菌、抗病毒的作用，为其药用开发提供了良好的前景。版权所有：John Wiley Sons， Ltd。
The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(11) and Fe(111) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB4 in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of P. vulgaris. Copyright (C) 2003 John Wiley Sons, Ltd.