Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules
Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules
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DOI：
10.1016/j.actbio.2012.06.003
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发表时间：
2012-09-01
影响因子：
9.7
通讯作者：
Ducheyne, Paul
中科院分区：
文献类型：
--
作者：
Bhattacharyya, Sanjib;Wang, Henson;Ducheyne, Paul
为了在较长时间内实现大生物分子的持续释放，我们专注于混合无机/有机纳米颗粒。我们合成了聚乙二醇 (PEG) 涂层的介孔二氧化硅纳米颗粒 (MSN)，其中掺入了胰蛋白酶抑制剂 (TI)，这是一种生长因子的模型蛋白质分子。由于掺入大蛋白质分子的目标，在 TI 掺入之前通过水热处理扩大了合成的 MSN 的孔径。没有聚合物薄膜的 MSN 的体外释放显示出最初的爆发，然后是连续释放。对于聚合物涂层的 MSN，初始爆发释放被完全抑制，并且在 4 周内实现了近似零级释放。 (C) 2012 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
With the goal of achieving constant release of large biological molecules over an extended period of time we focused on hybrid inorganic/organic nanoparticles. We synthesized poly(ethylene glycol) (PEG)coated mesoporous silica nanoparticles (MSNs) with incorporated trypsin inhibitor (TI), a model protein molecule for growth factors. Due to the goal of incorporating large protein molecules the pore size of the as-synthesized MSNs was expanded by a hydrothermal treatment prior to TI incorporation. In vitro release from the MSNs without the thin polymer film shows an initial burst followed by continuous release. In the case of polymer-coated MSNs the initial burst release was completely suppressed and approximate zero order release was achieved for 4 weeks. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.