Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke
Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke
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DOI：
10.1161/01.str.0000257304.21967.ba
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发表时间：
2007-03-01
期刊：
影响因子：
8.3
通讯作者：
Alexandrov, Andrei V.
中科院分区：
文献类型：
--
作者：
Saqqur, Maher;Uchino, Ken;Alexandrov, Andrei V.
背景和目的：本研究的目的是通过床边经颅多普勒定位的闭塞部位，检查多中心队列脑卒中患者静脉注射组织型纤溶酶原激活剂的临床结果和再通率。动脉内溶栓的血管造影研究表明，更近端的闭塞带来更大的血栓负担，从局部治疗中获益更少。方法：使用经验证的经颅多普勒特异性动脉闭塞标准（脑缺血血流溶栓等级），我们比较了显著恢复率（美国国立卫生研究院卒中量表评分）
Background and Purpose - The objective of this study was to examine clinical outcomes and recanalization rates in a multicenter cohort of stroke patients receiving intravenous tissue plasminogen activator by site of occlusion localized with bedside transcranial Doppler. Angiographic studies with intraarterial thrombolysis suggest more proximal occlusions carry greater thrombus burden and benefit less from local therapy.Methods - Using validated transcranial Doppler criteria for specific arterial occlusion ( Thrombolysis in Brain Ischemia flow grades), we compared the rate of dramatic recovery ( National Institutes of Health Stroke Scale score