Cervical Spine Disc Deformation During In Vivo Three-Dimensional Head Movements
Cervical Spine Disc Deformation During In Vivo Three-Dimensional Head Movements
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DOI：
10.1007/s10439-015-1424-2
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发表时间：
2016-05-01
影响因子：
3.8
通讯作者：
Kang, James
中科院分区：
文献类型：
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作者：
Anderst, William;Donaldson, William;Kang, James
虽然大量的研究表明，椎间盘细胞响应机械信号，很少有研究已经做了表征在椎间盘组织中的体内力学环境。本研究的目的是估计颈椎间盘应变在三维头部运动。29名年轻健康成年人在双平面X线摄影系统内进行了头部的全方位活动屈曲/伸展、侧弯和轴向旋转。三维椎骨运动学的确定使用一个有效的基于模型的跟踪技术。计算模型使用这些运动学来估计受试者特定的椎间盘变形（C3-4至C6-7）。计算每次运动、椎间盘水平和椎间盘区域的峰值压缩、牵引和剪切应变。峰值压缩应变和峰值剪切应变在屈曲/伸展期间最高（平均值+/- A 95%置信区间）（分别为32 +/- A 3和86 +/- A 8%），而峰值牵引应变在侧弯期间最高（57 +/- A 5%）。峰值压缩应变发生在C4-5（33 +/- A 4%），而峰值牵引和剪切应变发生在C3-4（分别为54 +/- A 8和83 +/- A 11%）。峰值压缩、牵引和剪切应变均发生在后外侧瓣环（分别为48 +/- A 4、80 +/- A 8和109 +/- A 12%）。这些峰值应变值可作为体外加载范例的边界条件，旨在评估生理性椎间盘变形的生物学反应。
Although substantial research demonstrates that intervertebral disc cells respond to mechanical signals, little research has been done to characterize the in vivo mechanical environment in the disc tissue. The objective of this study was to estimate cervical disc strain during three-dimensional head movements. Twenty-nine young healthy adults performed full range of motion flexion/extension, lateral bending, and axial rotation of the head within a biplane radiography system. Three-dimensional vertebral kinematics were determined using a validated model-based tracking technique. A computational model used these kinematics to estimate subject-specific intervertebral disc deformation (C3-4 to C6-7). Peak compression, distraction and shear strains were calculated for each movement, disc level, and disc region. Peak compression strain and peak shear strain were highest during flexion/extension (mean +/- A 95% confidence interval) (32 +/- A 3 and 86 +/- A 8%, respectively), while peak distraction strain was highest during lateral bending (57 +/- A 5%). Peak compression strain occurred at C4-5 (33 +/- A 4%), while peak distraction and shear strain occurred at C3-4 (54 +/- A 8 and 83 +/- A 11%, respectively). Peak compression, distraction, and shear strains all occurred in the posterior-lateral annulus (48 +/- A 4, 80 +/- A 8, and 109 +/- A 12%, respectively). These peak strain values may serve as boundary conditions for in vitro loading paradigms that aim to assess the biologic response to physiologic disc deformations.