Engagement of visual fixation suppresses sensory responsiveness and multisensory integration in the primate superior colliculus
Engagement of visual fixation suppresses sensory responsiveness and multisensory integration in the primate superior colliculus
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DOI：
10.1111/j.1460-9568.2003.02976.x
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发表时间：
2003-11-01
影响因子：
3.4
通讯作者：
Meredith, MA
中科院分区：
文献类型：
--
作者：
Bell, AH;Corneil, BD;Meredith, MA
上丘（SC）中层和深层的神经元除了为眼球扫视运动放电外，还经常表现出与感觉相关的活动。上级丘（SC）的中层和深层神经元除了为眼球扫视运动放电外，还表现出与感觉相关的活动。这两种活动模式可以联合收割机，因此感官反应的改变可以导致定向行为的变化。然而，行为因素会影响感觉活动吗？在这项研究中的恒河猴，我们隔离一个行为因素，视觉固定的状态，并检查其对感觉处理和多感觉整合的灵长类SC的影响。两个交错固定条件使用：FIX条件需要外源固定的一个可见的固定点;和FIX-BLINK条件，需要内源性固定在没有一个可见的固定点。SC的神经元的固定状态的影响，表现出较低水平的感觉活动和减少多感官的相互作用时，固定是外源性从事一个可见的固定点。这些结果是一致的主动视觉固定抑制反应外来刺激，从而表明，感官处理和多感官反应在SC不仅依赖于感官环境的物理特性，但也动态地影响动物的行为状态。
Neurons in the intermediate and deep layers of the superior colliculus (SC) often exhibit sensory-related activity in addition to discharging for saccadic eye movements. These two patterns of activity can combine so that modifications of the sensory response can lead to changes in orienting behaviour. Can behavioural factors, however, influence sensory activity? In this study of rhesus monkeys, we isolate one behavioural factor, the state of visual fixation, and examine its influences on sensory processing and multisensory integration in the primate SC. Two interleaved fixation conditions were used: a FIX condition requiring exogenous fixation of a visible fixation point; and a FIX-BLINK condition, requiring endogenous fixation in the absence of a visible fixation point. Neurons of the SC were influenced by fixation state, exhibiting both lower levels of sensory activity and reduced multisensory interactions when fixation was exogenously engaged on a visible fixation point. These results are consistent with active visual fixation suppressing responses to extraneous stimuli, and thus demonstrate that sensory processing and multisensory responses in the SC are not dependent solely on the physical properties of the sensory environment, but are also dynamically influenced by the behavioural state of the animal.