1H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters
1H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters
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DOI：
10.1016/j.atherosclerosis.2009.01.040
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发表时间：
2009-09-01
期刊：
影响因子：
5.3
通讯作者：
Paris, Alain
中科院分区：
文献类型：
--
作者：
Martin, Jean-Charles;Canlet, Cecile;Paris, Alain
饮食是调节动脉粥样硬化发生的重要环境因素。本研究的目的是使用传统方法和代谢组学方法评估不同乳制品对高脂仓鼠早期动脉粥样硬化形成的影响。除了非致动脉粥样硬化的低脂饮食外，仓鼠还摄入了高达 200 克/公斤的脂肪，这些脂肪是由各种乳脂或菜籽油 (CV) 制成的无水黄油或奶酪。主动脉胆固醇酯负荷被认为是早期动脉粥样硬化点，并且使用基于血浆 H-1 NMR 的代谢组学来测量与动脉粥样硬化相关的代谢变化。植物油奶酪饮食获得的动脉粥样硬化性最低，其次是乳脂奶酪饮食，而黄油饮食则观察到最大的动脉粥样硬化性（P
Diet is an important environmental factor modulating the onset of atherosclerosis. The aim of this study was to evaluate the effects of different dairy-based food products on early atherogenesis using both conventional and metabonomic approaches in hyperlipidemic hamsters. The hamsters received up to 200 g/kg of fat as anhydrous butter or cheese made from various milk fats or canola-based oil (CV), in addition to a non-atherogenic low-fat diet. Aortic cholesteryl ester loading was considered to be an early atherogenic point, and metabolic changes linked to atherogenesis were measured using plasma H-1 NMR-based metabonomics. The lowest atherogenicity was obtained with the plant-oil cheese diet, followed by the dairy fat cheese diet, while the greatest atherogenicity was observed with the butter diet (P