Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells
Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells
复制标题
DOI：
10.1126/science.278.5336.283
复制
发表时间：
1997-10-10
期刊：
影响因子：
56.9
通讯作者：
Porcelli, SA
中科院分区：
文献类型：
--
作者：
Moody, DB;Reinhold, BB;Porcelli, SA
人CD 1b蛋白向T细胞呈递脂质抗原，但分子机制尚不清楚。鉴定分枝杆菌葡萄糖单霉菌酸盐（GMM）作为CD 1b-呈递的糖脂允许确定其被T细胞识别的结构要求。GMM向CD 1b限制性T细胞的呈递不受其脂质尾部的实质性变化的影响，但对其碳水化合物或其他极性取代基的化学改变极其敏感。这些研究结果支持了这样的观点，即最近证明的疏水性CD 1沟结合脂抗原的酰基链相对非特异性，从而定位与T细胞抗原受体高度特异性相互作用的亲水性成分。
The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM) as a CD1b-presented glycolipid allowed determination of the structural requirements for its recognition by T cells. Presentation of GMM to CD1b-restricted T cells was not affected by substantial variations in its lipid tails, but was extremely sensitive to chemical alterations in its carbohydrate or other polar substituents. These findings support the view that the recently demonstrated hydrophobic CD1 groove binds the acyl chains of lipid antigens relatively nonspecifically, thereby positioning the hydrophilic components for highly specific interactions with T cell antigen receptors.