Silver(I)-glutathione biocoordination polymer hydrogel: effective antibacterial activity and improved cytocompatibility
Silver(I)-glutathione biocoordination polymer hydrogel: effective antibacterial activity and improved cytocompatibility
复制标题
银(I)-谷胱甘肽生物配位聚合物水凝胶：有效抗菌活性并改善细胞相容性
DOI：
10.1039/c1jm13693c
复制
发表时间：
2011-01-01
影响因子：
--
通讯作者：
Tang, Zhiyong
中科院分区：
文献类型：
--
作者：
Liu, Yong;Ma, Wanshun;Tang, Zhiyong
制备了一种Ag（I）-谷胱甘肽生物配位聚合物水凝胶，并通过Ca 2+离子进一步交联。与市售磺胺嘧啶银乳膏相比，交联Ag（I）-谷胱甘肽水凝胶具有更好的抗菌活性和更好的细胞相容性，是第一种基于生物配位聚合物的抗菌水凝胶，在生物医学领域具有潜在的应用前景。例如，在一个实施例中，烧伤敷料。
A Ag(I)-glutathione biocoordination polymer hydrogel is fabricated and further cross-linked by Ca2+ ions. Compared with commercial silver sulfadiazine cream, the cross-linked Ag(I)-glutathione hydrogel exhibits effective antibacterial activity and improved cytocompatibility, which represents the first antibacterial hydrogel based on biocoordination polymers and has potential application in the biomedical field, e. g., burn wound dressings.