Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression - A preliminary report
Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression - A preliminary report
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DOI：
10.1016/j.biopsych.2008.02.023
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发表时间：
2008-08-15
影响因子：
10.6
通讯作者：
Bauer, Moises Evandro
中科院分区：
文献类型：
--
作者：
Grassi-Oliveira, Rodrigo;Stein, Lilian Milnitsky;Bauer, Moises Evandro
背景：早期生活压力被认为是情感障碍易感性的中介。反复分离母体的动物模型显示，与下丘脑-垂体-肾上腺轴和记忆形成有关的特定脑区脑源性神经营养因子(BDNF)水平降低。此外，在严重抑郁障碍(MDD)和双相情感障碍中，脑源性神经营养因子水平也会降低。为探讨儿童期躯体疏忽(CPN)和血浆脑源性神经营养因子(BDNF)水平对成年女性复发性抑郁症患者记忆成绩的影响。方法：对17例复发性女性抑郁症患者(MDD+CPN组，n=17例)和17例非CPN组(MDD组，n=17例)和15例健康对照组(n=15例)进行血浆BDNF含量和言语记忆成绩的测定。记忆是通过韦施勒记忆量表的逻辑记忆部分进行评估的，修订后的韦施勒记忆量表用于立即和延迟回忆。采用酶联免疫吸附试验(ELISAs)检测脑源性神经营养因子(BDNF)。结果：重度抑郁症患者血浆BDNF浓度低于健康对照组(p<；.001)。重度抑郁障碍+CPN患者的脑源性神经营养因子水平甚至低于对照组和MDD患者(p<；0.05)。脑源性神经营养因子水平与心理发病率呈负相关，与记忆成绩呈正相关。回归模型显示，CPN的严重程度和低水平的血浆BDNF对即刻言语回忆的损害有预测作用。通过创伤后应激障碍(PTSD)的严重症状预测CPN和抑郁的严重程度以及记忆保持的严重程度。结论：CPN和血浆BDNF是与抑郁和言语记忆成绩相关的重要因素，尤其与编码过程有关。
Background: Early life stress has been suggested to mediate vulnerability to affective disorders. Animal models of repeated maternal separation have shown reduced brain-derived neurotrophic factor (BDNF) levels in specific brain regions implicated with hypothalamic-pituitary-adrenal axis and memory formation. In addition, BDNF levels are also reduced in major depressive disorder (MDD) and bipolar disorder. The aim of this study was to investigate whether childhood physical neglect (CPN) and plasma BDNF levels would impact on memory performance in adult female subjects with recurrent major depression.Methods: Recurrent female MDD outpatients with CPN (MDD + CPN, n = 17) and without CPN (MDD, n = 17) and healthy control subjects (n = 15) were assessed for plasma BDNF content and verbal memory performance. Memory was assessed through the logical memory component of the Weschler Memory Scale-Revised for immediate and delayed recall. Brain-derived neurotrophic factor was assessed with enzyme-linked immunosorbent assays (ELISAs).Results: Major depressive disorder patients showed lower plasma BDNF concentrations than healthy control subjects (p < .001). Major depressive disorder + CPN had even lower BDNF levels compared with control subjects and MDD (p < .05). Brain-derived neurotrophic factor levels were negatively related to psychological morbidity and positively correlated to memory performance. Regression models showed that severity of self-reported CPN and low plasma BDNF predicted impairment on immediate verbal recall. Delayed recall impairment was predicted by severity of CPN and depression and memory retention by posttraumatic stress disorder (PTSD) severity symptoms.Conclusions: Our data suggest that CPN and plasma BDNF are important factors associated with depression and verbal memory performance, particularly with encoding processes.