Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014
Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014
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DOI：
10.1002/cncr.32207
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发表时间：
2019-10-01
期刊：
影响因子：
6.2
通讯作者：
Il'yasova, Dora
中科院分区：
文献类型：
--
作者：
Scott, Lia C.;Mobley, Lee R.;Il'yasova, Dora
背景 三阴性乳腺癌 (TNBC) 与更具侵袭性的组织学、较差的预后和对激素治疗无反应有关。癌症研究必须找出导致差异的因素并注重预防。方法 作者利用美国癌症统计数据库，检查了 TNBC 与所有其他乳腺癌在年龄、种族/民族和诊断分期方面的差异。结果 2010年至2014年共发现乳腺癌病例1,151,724例，其中三阴性表型约占所有病例的8.4%。在未经调整的分析中，与非西班牙裔白人女性相比，非西班牙裔黑人女性（比值比 [OR]，2.27；95% CI，2.23-2.31）和西班牙裔女性（OR，1.22；95% CI，1.19-1.25）的诊断几率更高。女性老年
Background Triple-negative breast cancer (TNBC) has been associated with a more aggressive histology, poorer prognosis, and nonresponsiveness to hormone therapy. It is imperative that cancer research identify factors that drive disparities and focus on prevention. Methods Using the United States Cancer Statistics database, the authors examined differences between TNBCs compared with all other breast cancers with regard to age, race/ethnicity, and stage at diagnosis. Results A total of 1,151,724 cases of breast cancer were identified from 2010 through 2014, with the triple-negative phenotype accounting for approximately 8.4% of all cases. In unadjusted analyses, non-Hispanic black women (odds ratio [OR], 2.27; 95% CI, 2.23-2.31) and Hispanic women (OR, 1.22; 95% CI, 1.19-1.25) had higher odds of diagnosis when compared with non-Hispanic white women. Women aged