Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy
Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy
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DOI：
10.1002/adma.201003763
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发表时间：
2011-02-08
影响因子：
29.4
通讯作者：
Le Visage, Catherine
中科院分区：
文献类型：
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作者：
Brule, Severine;Levy, Michael;Le Visage, Catherine
海藻酸盐微珠与氧化铁纳米粒子加热器，携带阿霉素进行了研究，在体外同时药物靶向和局部发热（高热）。应用交变磁场（AMF）导致磁热疗增强阿霉素释放。AMF触发的药物释放和热疗表现出协同效应，并导致显著的肿瘤细胞死亡。
Alginate microbeads with iron oxide nanoparticle heaters that carry doxorubicin are investigated in vitro for simultaneous drug targeting and local heat generation (hyperthermia). Application of an alternative magnetic field (AMF) causes magnetic-hyperthermia-enhanced doxorubicin release. The AMF-triggered drug release and hyperthermia exhibit synergistic effects and result in significant tumor cell death.