Body mass index, lifestyles, physical performance and cognitive decline: The "Treviso Longeva (Trelong)" study
Body mass index, lifestyles, physical performance and cognitive decline: The "Treviso Longeva (Trelong)" study
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DOI：
10.1007/s12603-012-0397-1
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发表时间：
2013-04-01
影响因子：
5.8
通讯作者：
Regini, C.
中科院分区：
文献类型：
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作者：
Gallucci, M.;Mazzuco, S.;Regini, C.
风险因素，如体重指数（BMI），抑郁症，慢性病，吸烟和生活方式（如身体和表演活动，社会接触和阅读习惯）对老年人认知能力下降的相对贡献尚不清楚。我们探讨了这些变量与长寿的意大利老年人7年认知能力下降的关系。一项代表性的、年龄分层的人群样本纵向研究的次要数据分析。在意大利特雷维索的TREVISO LONGEVA（TRELONG）研究。120名男性和189名女性，年龄77岁及以上（平均年龄80.2 ± 6.9岁）随访7年后的幸存者。认知能力下降以2003年和2010年简易精神状态检查（MMSE）评分之间的差异衡量;在2003年基线记录的体重指数（BMI）、握力、短期体能测验（SPPB）评分、社会交往、阅读习惯、视力、听力、受教育程度、地中海饮食以及多种临床和调查数据中。在单独的单变量分析中，年龄、SPPB评分< 5、抑郁症状（GDS）和更多的合并症（CCI）与更大的认知下降相关。另外，较高的BMI、较高的握力、阅读习惯、视力和听力未恶化以及受教育程度是保护性的。在最终的多变量模型中，年龄和较高的BMI与更大的认知能力下降相关，而阅读习惯具有保护作用。SPPB评分< 5往往与更大的认知能力下降相关，尽管程度较弱。这些关联仍然与性别，学校教育，Charlson共病指数（CCI）和基线MMSE的多变量调整。年龄和较高的基线BMI，独立于性别，和其他混杂因素，是认知能力下降的危险因素。阅读习惯在意大利北方70岁以上的成年人中起着7年后的保护作用。身体机能低下往往与认知能力的下降有关，尽管这种联系很弱。
The relative contributions of risk factors, as body mass index (BMI), depression, chronic diseases, smoking, and lifestyles (as physical and performance activity, social contacts and reading habit) to cognitive decline in the elderly are unclear. We explored these variables in relation to 7-year cognitive decline in long-lived Italian elderly.Secondary data analysis of a longitudinal study of a representative, age-stratified, population sample.The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy.120 men and 189 women, age 77 years and older (mean age 80.2 +/- 6.9 years) survivors after seven years of follow up.Cognitive decline measured as difference between Mini-Mental State Examination (MMSE) score in 2003 and in 2010; Body mass index (BMI), handgrip, Short Physical Performance Battery (SPPB) score, social contacts, reading habit, sight, hearing, schooling, mediterranean diet and multiple clinical and survey data recorded at baseline in 2003.In separate univariate analyses, age, SPPB score < 5, depressive symptoms (GDS) and more comorbidities (CCI) were associated with greater cognitive decline. Otherwise higher BMI, higher handgrip, reading habit, non-deteriorated sight and hearing, and schooling were protective. In a final multivariate model, age and higher BMI were associated with greater cognitive decline while reading habits was protective. SPPB score < 5 tends, though weakly, to be associated with greater cognitive decline. These associations remained with multivariate adjustment for gender, schooling, Charlson co-morbidity index (CCI) and baseline MMSE.Age and higher baseline BMI, independent of gender, and other confounding factors, are risk factors for cognitive decline. Reading habit plays a protective role seven years later among northern Italian adults aged 70 years or older. Low physical performance tends, though weakly, to be associated with greater cognitive decline.