Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro
Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro
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DOI：
10.1016/0304-3940(96)12536-2
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发表时间：
1996-04-12
影响因子：
2.5
通讯作者：
Grafe, P
中科院分区：
文献类型：
--
作者：
Grosskreutz, J;Quasthoff, S;Grafe, P
最近已测试局部应用辣椒素用于治疗疼痛性周围神经病。在本研究中，探讨了辣椒素对从人类腓肠神经活检中分离出的神经束的复合动作电位的影响。辣椒素使C纤维成分减少30-60%；其余的C纤维对药物不敏感。研究发现C纤维对辣椒素的敏感性与其对河豚毒素（TTX）的抗性之间存在良好的相关性，即在TTX存在的情况下记录的C纤维动作电位被辣椒素完全阻断。抑制轴突钾电导后观察到的钙动作电位也被完全抑制。数据表明，在人周围神经附近使用辣椒素可能会阻止特定亚型 C 纤维的动作电位传导。
Topical application of capsaicin has been tested recently for treatment of painful peripheral neuropathy. In the present study, effects of capsaicin were explored on compound action potentials of isolated fascicles from human sural nerve biopsies. Capsaicin reduced the C fibre component by 30-60%; the remaining C fibres were not sensitive to the drug. A good correlation was found between the sensitivity of C fibres to capsaicin and their resistance to tetrodotoxin (TTX), i.e. C fibre action potentials recorded in the presence of TTX were completely blocked by capsaicin. Calcium action potentials seen after inhibition of axonal potassium conductances were also completely suppressed, The data indicate that application of capsaicin nearby human peripheral nerves might prevent action potential conduction in specific subtypes of C fibres.