The expression of platelet-derived endothelial cell growth factor in human bladder cancer
The expression of platelet-derived endothelial cell growth factor in human bladder cancer
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DOI：
10.1016/s0304-3835(98)00097-4
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发表时间：
1998-08-14
期刊：
影响因子：
9.7
通讯作者：
Saito, Y
中科院分区：
文献类型：
--
作者：
Sawase, K;Nomata, K;Saito, Y
血小板来源内皮细胞生长因子（Platelet-derived endothelial cell growth factor, PD-ECGF）是一种血管生成因子，在一些研究中，PD-ECGF/dTdRPase在几种癌症中的表达水平高于其周围正常组织。本研究通过免疫组织学方法评估PD-ECGF/dTdRPase在膀胱癌中的表达，并确定其是否与肿瘤分期、分级和复发相关。PD-ECGF/dTdRPase表达与肿瘤分级、分期相关。此外，在浅表性肿瘤中，PD-ECGF/dTdRPase表达与无复发率相关，可能是浅表性膀胱癌复发的预后因素。(C) 1998爱思唯尔科学爱尔兰有限公司版权所有。
Platelet-derived endothelial cell growth factor (PD-ECGF) is an angiogenic factor and in some studies PD-ECGF/dTdRPase expression levels in several kind of cancers were higher than in their surrounding normal tissues. In this study, we evaluated PD-ECGF/dTdRPase expression in bladder cancer by an immunohistological method and determined whether it correlated with tumor stage, grade and recurrence. PD-ECGF/dTdRPase expression was correlated with tumor grade and stage. Furthermore, among the superficial tumors, PD-ECGF/dTdRPase expression was correlated with a recurrence-free rate and thus it might be a prognostic factor for the recurrence of superficial bladder cancer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.