Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice
Plastic changes in the astrocyte GLUT1 glucose transporter and beta-tubulin microtubule protein following voluntary exercise in mice
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DOI：
10.1016/j.bbr.2012.11.025
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发表时间：
2013-03-01
影响因子：
2.7
通讯作者：
Messier, Claude
中科院分区：
文献类型：
--
作者：
Allen, Angela;Messier, Claude
葡萄糖是中枢和外周神经系统的主要能量底物，通过一系列促进性葡萄糖转运蛋白(GLUT)传递给神经元。大部分葡萄糖是通过位于毛细血管上皮细胞和包裹在毛细血管周围的星形胶质细胞上的葡萄糖转运蛋白1(GLUT1)运输到大脑的。神经元活动的变化与葡萄糖需求和局部大脑葡萄糖利用的增加有关。目前的研究表明，GLUT1的表达随着操作任务中代谢需求的增加而发生相应的变化。本研究的目的是在小鼠脑内检测自愿跑步诱导的神经元激活对血管GLUT1的可塑性表达和微管蛋白β-微管蛋白III(TuJ)所测量的神经元可塑性的影响。结果显示，接触跑轮48小时后，GLUT1、TuJ和GLUT1相关运动区星形胶质细胞血管终足的表达发生了可塑性变化。这些结果倾向于支持能量供应机制与神经元在新的训练经验后的可塑性重组之间的可塑性联系。(C)2012爱思唯尔B.V.保留所有权利。
Glucose, the predominant energy substrate of the central and peripheral nervous system, is delivered to neurons via a family of facilitative glucose transporters (GLUT). The majority of glucose is transported to the brain via glucose transporter 1 (GLUT1) located on epithelial cells of capillaries and on the astrocytes that wrap around them. Changes in neuronal activity are linked to increases in glucose demand and local cerebral glucose utilization. Current research has indicated a corresponding change in GLUT1 expression in response to increased metabolic demand in operant tasks. The purpose of this study was to examine, in the mouse brain, the effects of neuronal activation induced by voluntary running on the plastic expression of vascular GLUT1 and neuronal plasticity as measured by the microtubule protein beta-tubulin III (Tuj). The results showed that access to a running wheel for 48 h induced plastic changes in the expression of GLUT1, Tuj and GLUT1-associated estimate of astrocyte vascular endfeet in motor regions. The results tend to support the plastic association between mechanisms of energy supply and plastic reorganization of neurons following a new training experience. (C) 2012 Elsevier B.V. All rights reserved.