Myelodysplastic syndromes in patients younger than age 50
Myelodysplastic syndromes in patients younger than age 50
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DOI：
10.1200/jco.2006.07.5598
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发表时间：
2006-12-01
影响因子：
45.3
通讯作者：
Germing, Ulrich
中科院分区：
文献类型：
--
作者：
Kuendgen, Andrea;Strupp, Corinna;Germing, Ulrich
目的骨髓增生异常综合征（MDS）主要发生于老年人，但也可累及年轻人。后者需要特别考虑，以确定合适的候选人异基因干细胞移植，一个潜在的治愈方法进行治疗相关的并发症的高风险。患者和MethodsWe报告的最大系列的年轻MDS患者尚未，包括232例年龄小于50岁。将其临床特征和预后与2,496例50岁以上患者进行比较。
PurposeMyelodysplastic syndromes (MDS) mainly occur in the elderly but can affect younger individuals too. The latter require special consideration to identify suitable candidates for allogeneic stem-cell transplantation, a potentially curative approach carrying a high risk of treatment-related complications.Patients and MethodsWe report the largest series of young MDS patients as yet, including 232 patients younger than 50 years. Their clinical characteristics and prognosis are compared with 2,496 patients older than 50 years.ResultsSurvival was significantly longer in the younger versus older age group (40 v 23 months, respectively; P