Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.
Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control.
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DOI：
10.1513/pats.200806-054rm
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发表时间：
2009-05-01
期刊：
影响因子：
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通讯作者：
van der Vliet, Albert
中科院分区：
文献类型：
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作者：
Janssen-Heininger, Yvonne M W;Poynter, Matthew E;van der Vliet, Albert
最近大量的研究指出气道上皮细胞在过敏性炎症肺的炎症反应中的重要性。研究还指出氧化应激在慢性炎症性疾病的病理生理学中的作用。本文就气道上皮细胞在变应性炎症中的作用及核因子κ B的相关性作一综述。我们还提供了一个角度的作用，氧化剂可以发挥在肺内稳态的读者，并解决的概念“氧化还原生物学”。“此外，我们回顾了最近的证据，强调了氧化剂对核因子kappaB活化和炎症的潜在抑制作用，并讨论了最近的检测方法，这些方法可用于探测氧化剂在肺生物学中的功能作用。
A wealth of recent studies points to the importance of airway epithelial cells in the orchestration of inflammatory responses in the allergic inflamed lung. Studies also point to a role of oxidative stress in the pathophysiology of chronic inflammatory diseases. This article provides a perspective on the significance of airway epithelial cells in allergic inflammation, and reviews the relevance of the transcription factor, nuclear factor kappaB, herein. We also provide the reader with a perspective on the role that oxidants can play in lung homeostasis, and address the concept of "redox biology." In addition, we review recent evidence that highlights potential inhibitory roles of oxidants on nuclear factor kappaB activation and inflammation, and discuss recent assays that have become available to probe the functional roles of oxidants in lung biology.