Improvement of motor function with noninvasive cortical stimulation in a patient with chronic stroke
Improvement of motor function with noninvasive cortical stimulation in a patient with chronic stroke
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DOI：
10.1177/1545968304272698
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发表时间：
2005-03-01
影响因子：
4.2
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Hummel, F;Cohen, LG
本文报道了经颅直流电刺激（tDCS）对慢性皮质下缺血性中风患者运动功能的影响，tDCS是一种增强健康人皮层可塑性的技术。在双盲方案中，tDCS而非sham应用于受影响半球的运动区域，可以改善捏力，Jebsen-Taylor手功能测试和麻痹手的简单反应时间，其持续时间至少超过刺激期40min。这些变化伴随着皮质运动性兴奋性的增加，通过增强的招募曲线和减少皮质内对经颅磁刺激的抑制来识别。这些结果证明了无创脑刺激对中风患者运动功能的有益影响，并提出了它在神经康复中的潜在应用假设。
This manuscript reports the effects of transcranial DC stimulation (tDCS), a technique that enhances cortical plasticity in healthy humans, on motor function in a patient with chronic subcortical ischemic stroke. tDCS but not sham applied in a double-blind protocol to motor region of the affected hemisphere led to improvements in pinch force, Jebsen-Taylor Hand Function Test, and simple reaction times in the paretic hand that outlasted the stimulation period for at least 40min. These changes were accompanied by increased corticomotor excitability identified by enhanced recrutiment curves and reduced intracortical inhibition to transcranical magnetic stimulation. These results document a beneficial effect of noninvasive brain stimulation on motor function in a human patient with stroke and raise the hypothesis of it potential application in neurorehabilitation.